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Table 4 Final linear regression model adjusting for all key variables with average HIF3A.2 methylation as outcome

From: Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

  Average across HIF3A.2 (n = 513)
β (SE) p 95% CI
GDM 4.62 (1.77) 0.009 1.14 to 8.09
Pre-eclampsia − 5.20 (2.19) 0.02 − 9.51 to − 0.89
Sex (male) − 3.77 (0.76) < 0.001 − 5.26 to − 2.29
Gestational age (weeks) 1.21 (0.27) < 0.001 0.68 to 1.74
rs3810298    
 C/T − 8.31 (0.97) < 0.001 − 10.22 to − 6.41
 T/T − 16.91 (2.73) < 0.001 − 22.27 to − 11.54
  1. Effect sizes (β) given as percentage methylation. β for rs3810298 categories is the difference from homozygote major allele (C/C). GDM gestational diabetes, SE standard error, CI confidence interval. No other SNPs were strongly associated with HIF3A.2 methylation after adjustment for rs3810298, and a linear regression model with just rs3810298 accounted for a similar amount of variation in HIF3A.2 methylation measures and the model with six SNPs (R2 for minimal model = 0.162, R2 for full model = 0.177, p = 0.29)