Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

Clinical Epigenetics

Table 4 Final linear regression model adjusting for all key variables with average HIF3A.2 methylation as outcome

Effect sizes (β) given as percentage methylation. β for rs3810298 categories is the difference from homozygote major allele (C/C). GDM gestational diabetes, SE standard error, CI confidence interval. No other SNPs were strongly associated with HIF3A.2 methylation after adjustment for rs3810298, and a linear regression model with just rs3810298 accounted for a similar amount of variation in HIF3A.2 methylation measures and the model with six SNPs (R² for minimal model = 0.162, R² for full model = 0.177, p = 0.29)

ISSN: 1868-7083