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Table 4 Final linear regression model adjusting for all key variables with average HIF3A.2 methylation as outcome

From: Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

 

Average across HIF3A.2 (n = 513)

β (SE)

p

95% CI

GDM

4.62 (1.77)

0.009

1.14 to 8.09

Pre-eclampsia

− 5.20 (2.19)

0.02

− 9.51 to − 0.89

Sex (male)

− 3.77 (0.76)

< 0.001

− 5.26 to − 2.29

Gestational age (weeks)

1.21 (0.27)

< 0.001

0.68 to 1.74

rs3810298

   

 C/T

− 8.31 (0.97)

< 0.001

− 10.22 to − 6.41

 T/T

− 16.91 (2.73)

< 0.001

− 22.27 to − 11.54

  1. Effect sizes (β) given as percentage methylation. β for rs3810298 categories is the difference from homozygote major allele (C/C). GDM gestational diabetes, SE standard error, CI confidence interval. No other SNPs were strongly associated with HIF3A.2 methylation after adjustment for rs3810298, and a linear regression model with just rs3810298 accounted for a similar amount of variation in HIF3A.2 methylation measures and the model with six SNPs (R2 for minimal model = 0.162, R2 for full model = 0.177, p = 0.29)