Clinical Epigenetics

Table 2 Associations of cohort characteristics with average HIF3A.1 and HIF3A.2 methylation

From: Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

Characteristics	Average HIF3A.1 methylation n = 423		Average HIF3A.2 methylation n = 609
Maternal
	r	p	r	p
Age at conception (years)	0.01	0.80	-0.01	0.76
Pre-pregnancy BMI (kg/m²)	-0.01	0.81	0.04	0.40
	Effect (SE)	p	Effect (SE)	p
Smoked during pregnancy (any)	0.01 (0.66)	0.99	0.63 (1.10)	0.56
Gestational diabetes	0.04 (1.19)	0.97	3.53 (2.01)	0.08
Pre-eclampsia	0.09 (1.24)	0.94	− 6.38 (2.32)	0.006
Infant
	r	p	r	p
Gestational age (weeks)	− 0.08	0.10	0.19	< 0.001
Birth weight (g)	− 0.05	0.32	0.09	0.03
Birth weight z-score	− 0.03	0.61	0.02	0.61
Triceps+subscapular sum (mm)	− 0.01	0.89	0.03	0.54
	Effect (SE)	p	Effect (SE)	p
Sex (male)	0.78 (0.44)	0.08	− 3.87 (0.78)	< 0.001

Effect size given as difference in percentage methylation. r correlation coefficient, SE standard error. p values for binary measures (smoking during pregnancy, gestational diabetes, pre-eclampsia, and male infant sex) are from unpaired two-tailed Student’s t tests comparing the exposed group to the unexposed group. p values for continuous measures are from correlation coefficient tests

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ISSN: 1868-7083

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