|
Characteristics
|
Average HIF3A.1 methylation n = 423
|
Average HIF3A.2 methylation n = 609
|
|---|
|
Maternal
|
| |
r
|
p
|
r
|
p
|
|
Age at conception (years)
|
0.01
|
0.80
|
-0.01
|
0.76
|
|
Pre-pregnancy BMI (kg/m2)
|
-0.01
|
0.81
|
0.04
|
0.40
|
| |
Effect (SE)
|
p
|
Effect (SE)
|
p
|
|
Smoked during pregnancy (any)
|
0.01 (0.66)
|
0.99
|
0.63 (1.10)
|
0.56
|
|
Gestational diabetes
|
0.04 (1.19)
|
0.97
|
3.53 (2.01)
|
0.08
|
|
Pre-eclampsia
|
0.09 (1.24)
|
0.94
|
− 6.38 (2.32)
|
0.006
|
|
Infant
|
| |
r
|
p
|
r
|
p
|
|
Gestational age (weeks)
|
− 0.08
|
0.10
|
0.19
|
< 0.001
|
|
Birth weight (g)
|
− 0.05
|
0.32
|
0.09
|
0.03
|
|
Birth weight z-score
|
− 0.03
|
0.61
|
0.02
|
0.61
|
|
Triceps+subscapular sum (mm)
|
− 0.01
|
0.89
|
0.03
|
0.54
|
| |
Effect (SE)
|
p
|
Effect (SE)
|
p
|
|
Sex (male)
|
0.78 (0.44)
|
0.08
|
− 3.87 (0.78)
|
< 0.001
|
- Effect size given as difference in percentage methylation. r correlation coefficient, SE standard error. p values for binary measures (smoking during pregnancy, gestational diabetes, pre-eclampsia, and male infant sex) are from unpaired two-tailed Student’s t tests comparing the exposed group to the unexposed group. p values for continuous measures are from correlation coefficient tests
