Characteristics

Average HIF3A.1 methylation n = 423

Average HIF3A.2 methylation n = 609


Maternal


r

p

r

p

Age at conception (years)

0.01

0.80

0.01

0.76

Prepregnancy BMI (kg/m^{2})

0.01

0.81

0.04

0.40


Effect (SE)

p

Effect (SE)

p

Smoked during pregnancy (any)

0.01 (0.66)

0.99

0.63 (1.10)

0.56

Gestational diabetes

0.04 (1.19)

0.97

3.53 (2.01)

0.08

Preeclampsia

0.09 (1.24)

0.94

− 6.38 (2.32)

0.006

Infant


r

p

r

p

Gestational age (weeks)

− 0.08

0.10

0.19

< 0.001

Birth weight (g)

− 0.05

0.32

0.09

0.03

Birth weight zscore

− 0.03

0.61

0.02

0.61

Triceps+subscapular sum (mm)

− 0.01

0.89

0.03

0.54


Effect (SE)

p

Effect (SE)

p

Sex (male)

0.78 (0.44)

0.08

− 3.87 (0.78)

< 0.001

 Effect size given as difference in percentage methylation. r correlation coefficient, SE standard error. p values for binary measures (smoking during pregnancy, gestational diabetes, preeclampsia, and male infant sex) are from unpaired twotailed Student’s t tests comparing the exposed group to the unexposed group. p values for continuous measures are from correlation coefficient tests