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Table 2 Associations of cohort characteristics with average HIF3A.1 and HIF3A.2 methylation

From: Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

Characteristics Average HIF3A.1 methylation n = 423 Average HIF3A.2 methylation n = 609
Maternal
  r p r p
Age at conception (years) 0.01 0.80 -0.01 0.76
Pre-pregnancy BMI (kg/m2) -0.01 0.81 0.04 0.40
  Effect (SE) p Effect (SE) p
Smoked during pregnancy (any) 0.01 (0.66) 0.99 0.63 (1.10) 0.56
Gestational diabetes 0.04 (1.19) 0.97 3.53 (2.01) 0.08
Pre-eclampsia 0.09 (1.24) 0.94 − 6.38 (2.32) 0.006
Infant
  r p r p
Gestational age (weeks) − 0.08 0.10 0.19 < 0.001
Birth weight (g) − 0.05 0.32 0.09 0.03
Birth weight z-score − 0.03 0.61 0.02 0.61
Triceps+subscapular sum (mm) − 0.01 0.89 0.03 0.54
  Effect (SE) p Effect (SE) p
Sex (male) 0.78 (0.44) 0.08 − 3.87 (0.78) < 0.001
  1. Effect size given as difference in percentage methylation. r correlation coefficient, SE standard error. p values for binary measures (smoking during pregnancy, gestational diabetes, pre-eclampsia, and male infant sex) are from unpaired two-tailed Student’s t tests comparing the exposed group to the unexposed group. p values for continuous measures are from correlation coefficient tests
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