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Table 3 Robust multivariable regression analysis of cg05575921 methylation association with smoking

From: Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells

Model Model co-variates Smoking parameter estimate Smoking parameter estimate, p value* Model adjusted r2
Model 1. Adjusted for 6 cell types (estimated without nRBCest) cg05575921 = smoking status + gestational age + infant sex + race + CD8 T cells + CD4 T cells+ natural killer cells + B cells + monocytes + granulocytes − 0.1284 2.11E−20 0.60
Model 2. Adjusted for 6 cell types (estimated without nRBCest) and log10nRBCabs cg05575921 = smoking status + gestational age + infant sex + race +CD8 T cells + CD4 T cells+ natural killer cells + B cells + monocytes + granulocytes + log10nRBCsabs − 0.1388 1.69E−49 0.66
Model 3. Adjusted for 7 cell types (including nRBCest) cg05575921 = smoking status + gestational age + infant sex + race + CD8 T cells + CD4 T cells+ natural killer cells + B cells + monocytes + granulocytes + nRBCest − 0.1251 1.69E−33 0.61
  1. Models 1 and 2 used cell type percentages calculated with the 6 cell-type de Goede deconvolution model [11]
  2. *The statistical significance cutoff following adjustment for multiple comparisons is p < 0.0125