Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein

Clinical Epigenetics

Table 4 The methylation status of CpG locus (the total and each tested) at OXTR gene promoter. The data was expressed as mean ± SEM. PE pre-eclampsia, NP normal pregnant. ***P < 0.001

Gene	Position	NP	PE
OXTR	1	0.068 ± 0.019	0.063 ± 0.013
	2	0.054 ± 0.008	0.085 ± 0.019
	3	0.050 ± 0.012	0.052 ± 0.007
	4	0.076 ± 0.026	0.084 ± 0.017
	5	0.063 ± 0.021	0.073 ± 0.013
	6	0.065 ± 0.021	0.069 ± 0.015
	7	0.041 ± 0.010	0.060 ± 0.016
	8	0.045 ± 0.004	0.083 ± 0.017
	9	0.076 ± 0.011	0.075 ± 0.012
	10	0.090 ± 0.014	0.118 ± 0.021
	11	0.056 ± 0.020	0.065 ± 0.011
	12	0.123 ± 0.014	0.121 ± 0.015
	13	0.065 ± 0.009	0.096 ± 0.022
	14	0.082 ± 0.018	0.103 ± 0.015
	15	0.109 ± 0.022	0.122 ± 0.015
	16	0.053 ± 0.014	0.098 ± 0.009
	17	0.069 ± 0.026	0.085 ± 0.017
	18	0.122 ± 0.018	0.114 ± 0.015
	19	0.063 ± 0.010	0.060 ± 0.009
	20	0.056 ± 0.019	0.083 ± 0.007
	21	0.081 ± 0.022	0.108 ± 0.027
	22	0.069 ± 0.022	0.097 ± 0.015
	Average	0.0716 ± 0.0024	0.0870 ± 0.0013***

ISSN: 1868-7083