Fig. 6
From: Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein
DNA methylation of CpG locus at PKCΒ gene promoter in human umbilical vein. a One CpG island that contains 44 CpG sites, located at positions + 27 to + 321 from TSS at PKCΒ gene promoter. b mRNA levels of PKCΒ in HUVECs after treatment with 5-Aza. c–e The mean methylation status of CpG locus (the total and each tested) at PKCΒ gene promoter in HUV (N = 30 each group). f DNA methylation/mRNA correlation plots for PKCΒ gene identified by causal inference test (N = 30 each group). g mRNA levels of OXTR gene in normal and pre-eclamptic HUVECs after 5-Aza treatment (N = 8 each group). Error bars denote SEM.*P < 0.05; **P < 0.01; ***P < 0.001. N number of participants