Fig. 3
From: Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein
The decreased sensitivity of AVP and OXT was dependent on PKC pathway. a PDBu induced vasoconstrictions in HUV (N = 12, n = 26 each group). b The mRNA levels of PKCα, PKCβ, PKCγ, PKCδ, and PKCε in HUV determined by qRT-PCR (N = 40 each group). c The protein levels of PKCβ in HUV determined by Western blot. d The inhibitory effect of GF109203X on AVP-induced contractions in HUV (N = 12, n = 19 each group). e The inhibitory effect of GF109203X on OXT-induced contractions in HUV (N = 12, n = 18 each group). GF109203X, PKC antagonist; PDBu, Phorbol 12, 13-dibutyrate (PKC activator). Error bars denote SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ns no significances, N number of participants, n number of HUV rings