DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Clinical Epigenetics

Table 3 Mendelian randomization analysis of top differentially methylated CpGs tested against 106 diseases

Exposure	Gene	Disease	β	SE	P value	FDR P value	Unit
cg15578140	MIR548F3	Inflammatory bowel disease	− 0.104	0.018	3.73E−09	2.54E−07	Log odds
cg09935388	GFI1	Inflammatory bowel disease	− 0.152	0.034	7.27E−06	2.18E−04	Log odds
cg04598670	Unknown	Inflammatory bowel disease	− 0.410	0.091	7.27E−06	5.24E−04	Log odds
cg09935388	GFI1	Crohn’s disease	− 0.162	0.040	4.74E−05	7.12E−04	Log odds
cg04598670	Unknown	Crohn’s disease	− 0.439	0.108	4.74E−05	1.71E−03	Log odds
cg09935388	GFI1	Ulcerative colitis	− 0.160	0.042	1.47E−04	1.47E−03	Log odds
cg04598670	Unknown	Ulcerative colitis	− 0.433	0.114	1.47E−04	3.52E−03	Log odds
cg25189904	GNG12	Schizophrenia	− 0.222	0.053	3.37E−05	1.82E−03	Log odds

Only significant associations (P_FDR < 0.05) are shown
GFI1 growth factor independent protein 1, MIR548F3 microRNA 548f-3, GNG12 guanine nucleotide binding protein gamma 12, β effect size estimate, SE standard error FDR false discovery rate

ISSN: 1868-7083