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Table 1 Association of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation

From: DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

CpG Chr Position Gene β (SE) P value
cg04180046 7 45002736 MYO1G 0.045 (0.003) 2.60E−54
cg12803068 7 45002919 MYO1G 0.077 (0.005) 5.70E−45
cg22132788 7 45002486 MYO1G 0.045 (0.003) 6.80E−38
cg19089201 7 45002287 MYO1G 0.035 (0.003) 1.20E−31
cg05549655 15 75019143 CYP1A1 0.010 (0.001) 1.00E−28
cg25949550 7 145814306 CNTNAP2 − 0.007 (0.001) 5.40E−27
cg18493761 11 125386885   0.037 (0.004) 7.30E−21
cg15507334 10 14372913 FRMD4A 0.024 (0.003) 1.80E−20
cg14179389 1 92947961 GFI1 − 0.028 (0.003) 5.00E−20
cg00253658 16 54210496   0.037 (0.004) 3.40E−19
cg17924476 5 323794 AHRR 0.024 (0.003) 4.40E−19
cg13570656 15 75019196 CYP1A1 0.036 (0.004) 7.40E−19
cg11813497 10 14372879 FRMD4A 0.026 (0.003) 9.30E−19
cg22549041 15 75019251 CYP1A1 0.041 (0.005) 2.60E−18
cg05575921 5 373378 AHRR − 0.019 (0.002) 3.50E−18
cg12101586 15 75019203 CYP1A1 0.032 (0.004) 1.20E−17
cg18092474 15 75019302 CYP1A1 0.036 (0.004) 1.50E−17
cg11924019 15 75019283 CYP1A1 0.013 (0.002) 2.90E−16
cg25464840 10 14372910 FRMD4A 0.019 (0.002) 9.30E−16
cg00213123 15 75019070 CYP1A1 0.012 (0.002) 7.80E−15
cg11207515 7 146904205 CNTNAP2 − 0.023 (0.003) 1.00E−13
cg14157435 2 206628692 NRP2 − 0.046 (0.006) 1.10E−13
cg05348875 2 206628625 NRP2 − 0.040 (0.006) 7.60E−13
cg01952185 5 134813213   0.019 (0.003) 3.30E−12
cg22308949 2 206628553 NRP2 − 0.022 (0.003) 4.40E−12
cg05204104 2 235403141 ARL4C 0.017 (0.003) 4.80E−12
cg11641006 2 235213874   0.017 (0.003) 7.90E−12
cg09935388 1 92947588 GFI1 − 0.029 (0.004) 1.10E−11
cg05697249 11 111789693 C11orf52 0.015 (0.002) 1.30E−11
cg21161138 5 399360 AHRR − 0.013 (0.002) 1.50E−11
cg26681628 16 54210550   0.018 (0.003) 1.80E−11
cg11025974 2 152830521 CACNB4 0.016 (0.002) 9.10E−11
cg15016771 2 235403218 ARL4C 0.008 (0.001) 1.00E−10
cg11429111 5 134813329   0.014 (0.002) 1.30E−10
cg25189904 1 68299493 GNG12 − 0.020 (0.003) 1.30E−10
cg06758350 21 36259460 RUNX1 0.030 (0.005) 1.70E−10
cg17852385 15 75019188 CYP1A1 0.010 (0.002) 2.60E−10
cg01664727 21 36258423 RUNX1 0.027 (0.004) 2.60E−10
cg20344448 10 14372431 FRMD4A 0.014 (0.002) 2.80E−10
cg00794911 6 166260532   − 0.012 (0.002) 5.20E−10
cg22698744 21 36263808 RUNX1 0.023 (0.004) 7.30E−10
cg03142697 21 36258497 RUNX1 0.016 (0.003) 8.10E−10
cg14563637 9 98931801   0.016 (0.003) 1.20E−09
cg15091747 21 36262896 RUNX1 0.014 (0.002) 1.20E−09
cg12984635 19 44032076 ETHE1 0.015 (0.002) 2.20E−09
cg01825213 9 98979965   0.019 (0.003) 2.50E−09
cg12477880 21 36259241 RUNX1 0.038 (0.006) 2.80E−09
cg17199018 8 28206278 ZNF395 − 0.017 (0.003) 3.90E−09
cg00174179 3 49450293 RHOA;TCTA − 0.006 (0.001) 7.00E−09
cg15578140 7 147718109 MIR548F3;CNTNAP2 0.011 (0.002) 7.50E−09
cg14540913 9 132458514 PRRX2 0.013 (0.002) 7.60E−09
cg18132363 6 166260572   − 0.019 (0.003) 7.60E−09
cg21253335 5 87835928   0.017 (0.003) 1.30E−08
cg25879142 7 4671391   0.018 (0.003) 1.80E−08
cg11845417 11 111789613 C11orf52 0.011 (0.002) 2.40E−08
cg20117519 7 8429907   0.022 (0.004) 2.40E−08
cg05783384 2 218843735   0.021 (0.004) 2.60E−08
cg13822849 9 137999757 OLFM1 0.007 (0.001) 2.90E−08
cg16449012 4 17781880 FAM184B 0.014 (0.002) 3.10E−08
cg05634495 6 122364658   0.016 (0.003) 3.10E−08
cg08644678 4 17711202 FAM184B 0.009 (0.002) 3.10E−08
cg13834112 15 90361639   0.013 (0.002) 3.60E−08
cg06635952 2 70025869 ANXA4 0.011 (0.002) 5.50E−08
cg14485097 7 4671479   0.016 (0.003) 7.40E−08
cg04598670 7 68697651   − 0.019 (0.003) 8.30E−08
cg03252786 11 125106056 PKNOX2 0.006 (0.001) 8.70E−08
cg04749740 2 65935124   0.015 (0.003) 9.20E−08
cg15325070 1 2792704   0.014 (0.003) 9.20E−08
cg04358214 16 67143304 C16orf70 0.022 (0.004) 9.60E−08
  1. The analyses were conducted separately in each participating cohort adjusted for study-specific covariates as necessary, and combined using inverse-variance weighted fixed-effects meta-analysis
  2. Chr chromosome, β effect size estimate, SE standard error