Table 1 Association of exposure to maternal smoking during pregnancy and offspring peripheral blood DNA methylation
From: DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
CpG | Chr | Position | Gene | β (SE) | P value |
|---|---|---|---|---|---|
cg04180046 | 7 | 45002736 | MYO1G | 0.045 (0.003) | 2.60E−54 |
cg12803068 | 7 | 45002919 | MYO1G | 0.077 (0.005) | 5.70E−45 |
cg22132788 | 7 | 45002486 | MYO1G | 0.045 (0.003) | 6.80E−38 |
cg19089201 | 7 | 45002287 | MYO1G | 0.035 (0.003) | 1.20E−31 |
cg05549655 | 15 | 75019143 | CYP1A1 | 0.010 (0.001) | 1.00E−28 |
cg25949550 | 7 | 145814306 | CNTNAP2 | − 0.007 (0.001) | 5.40E−27 |
cg18493761 | 11 | 125386885 | 0.037 (0.004) | 7.30E−21 | |
cg15507334 | 10 | 14372913 | FRMD4A | 0.024 (0.003) | 1.80E−20 |
cg14179389 | 1 | 92947961 | GFI1 | − 0.028 (0.003) | 5.00E−20 |
cg00253658 | 16 | 54210496 | 0.037 (0.004) | 3.40E−19 | |
cg17924476 | 5 | 323794 | AHRR | 0.024 (0.003) | 4.40E−19 |
cg13570656 | 15 | 75019196 | CYP1A1 | 0.036 (0.004) | 7.40E−19 |
cg11813497 | 10 | 14372879 | FRMD4A | 0.026 (0.003) | 9.30E−19 |
cg22549041 | 15 | 75019251 | CYP1A1 | 0.041 (0.005) | 2.60E−18 |
cg05575921 | 5 | 373378 | AHRR | − 0.019 (0.002) | 3.50E−18 |
cg12101586 | 15 | 75019203 | CYP1A1 | 0.032 (0.004) | 1.20E−17 |
cg18092474 | 15 | 75019302 | CYP1A1 | 0.036 (0.004) | 1.50E−17 |
cg11924019 | 15 | 75019283 | CYP1A1 | 0.013 (0.002) | 2.90E−16 |
cg25464840 | 10 | 14372910 | FRMD4A | 0.019 (0.002) | 9.30E−16 |
cg00213123 | 15 | 75019070 | CYP1A1 | 0.012 (0.002) | 7.80E−15 |
cg11207515 | 7 | 146904205 | CNTNAP2 | − 0.023 (0.003) | 1.00E−13 |
cg14157435 | 2 | 206628692 | NRP2 | − 0.046 (0.006) | 1.10E−13 |
cg05348875 | 2 | 206628625 | NRP2 | − 0.040 (0.006) | 7.60E−13 |
cg01952185 | 5 | 134813213 | 0.019 (0.003) | 3.30E−12 | |
cg22308949 | 2 | 206628553 | NRP2 | − 0.022 (0.003) | 4.40E−12 |
cg05204104 | 2 | 235403141 | ARL4C | 0.017 (0.003) | 4.80E−12 |
cg11641006 | 2 | 235213874 | 0.017 (0.003) | 7.90E−12 | |
cg09935388 | 1 | 92947588 | GFI1 | − 0.029 (0.004) | 1.10E−11 |
cg05697249 | 11 | 111789693 | C11orf52 | 0.015 (0.002) | 1.30E−11 |
cg21161138 | 5 | 399360 | AHRR | − 0.013 (0.002) | 1.50E−11 |
cg26681628 | 16 | 54210550 | 0.018 (0.003) | 1.80E−11 | |
cg11025974 | 2 | 152830521 | CACNB4 | 0.016 (0.002) | 9.10E−11 |
cg15016771 | 2 | 235403218 | ARL4C | 0.008 (0.001) | 1.00E−10 |
cg11429111 | 5 | 134813329 | 0.014 (0.002) | 1.30E−10 | |
cg25189904 | 1 | 68299493 | GNG12 | − 0.020 (0.003) | 1.30E−10 |
cg06758350 | 21 | 36259460 | RUNX1 | 0.030 (0.005) | 1.70E−10 |
cg17852385 | 15 | 75019188 | CYP1A1 | 0.010 (0.002) | 2.60E−10 |
cg01664727 | 21 | 36258423 | RUNX1 | 0.027 (0.004) | 2.60E−10 |
cg20344448 | 10 | 14372431 | FRMD4A | 0.014 (0.002) | 2.80E−10 |
cg00794911 | 6 | 166260532 | − 0.012 (0.002) | 5.20E−10 | |
cg22698744 | 21 | 36263808 | RUNX1 | 0.023 (0.004) | 7.30E−10 |
cg03142697 | 21 | 36258497 | RUNX1 | 0.016 (0.003) | 8.10E−10 |
cg14563637 | 9 | 98931801 | 0.016 (0.003) | 1.20E−09 | |
cg15091747 | 21 | 36262896 | RUNX1 | 0.014 (0.002) | 1.20E−09 |
cg12984635 | 19 | 44032076 | ETHE1 | 0.015 (0.002) | 2.20E−09 |
cg01825213 | 9 | 98979965 | 0.019 (0.003) | 2.50E−09 | |
cg12477880 | 21 | 36259241 | RUNX1 | 0.038 (0.006) | 2.80E−09 |
cg17199018 | 8 | 28206278 | ZNF395 | − 0.017 (0.003) | 3.90E−09 |
cg00174179 | 3 | 49450293 | RHOA;TCTA | − 0.006 (0.001) | 7.00E−09 |
cg15578140 | 7 | 147718109 | MIR548F3;CNTNAP2 | 0.011 (0.002) | 7.50E−09 |
cg14540913 | 9 | 132458514 | PRRX2 | 0.013 (0.002) | 7.60E−09 |
cg18132363 | 6 | 166260572 | − 0.019 (0.003) | 7.60E−09 | |
cg21253335 | 5 | 87835928 | 0.017 (0.003) | 1.30E−08 | |
cg25879142 | 7 | 4671391 | 0.018 (0.003) | 1.80E−08 | |
cg11845417 | 11 | 111789613 | C11orf52 | 0.011 (0.002) | 2.40E−08 |
cg20117519 | 7 | 8429907 | 0.022 (0.004) | 2.40E−08 | |
cg05783384 | 2 | 218843735 | 0.021 (0.004) | 2.60E−08 | |
cg13822849 | 9 | 137999757 | OLFM1 | 0.007 (0.001) | 2.90E−08 |
cg16449012 | 4 | 17781880 | FAM184B | 0.014 (0.002) | 3.10E−08 |
cg05634495 | 6 | 122364658 | 0.016 (0.003) | 3.10E−08 | |
cg08644678 | 4 | 17711202 | FAM184B | 0.009 (0.002) | 3.10E−08 |
cg13834112 | 15 | 90361639 | 0.013 (0.002) | 3.60E−08 | |
cg06635952 | 2 | 70025869 | ANXA4 | 0.011 (0.002) | 5.50E−08 |
cg14485097 | 7 | 4671479 | 0.016 (0.003) | 7.40E−08 | |
cg04598670 | 7 | 68697651 | − 0.019 (0.003) | 8.30E−08 | |
cg03252786 | 11 | 125106056 | PKNOX2 | 0.006 (0.001) | 8.70E−08 |
cg04749740 | 2 | 65935124 | 0.015 (0.003) | 9.20E−08 | |
cg15325070 | 1 | 2792704 | 0.014 (0.003) | 9.20E−08 | |
cg04358214 | 16 | 67143304 | C16orf70 | 0.022 (0.004) | 9.60E−08 |