Fig. 3
From: DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Visualization of the dose-response effect of the intensity of maternal smoking in pregnancy (x-axis) on offspring blood DNA methylation (y-axis) for top four CpG sites in four gene regions (AHRR, CYP1A1, MYO1G, GFI1). Prediction estimates and their 95% confidence intervals plotted based on generalized additive mixed models, with other covariates (offspring sex, body mass index, smoking status, population stratification, and technical covariates) set at their mean (continuous variables) or mode (categorical variables). The density plots represent the distribution of the cigarettes smoked per day in pregnancy. The plots are truncated at five cigarettes per day in pregnancy (containing 94% of full data)