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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

Fig. 2

True 5mC and 5hmC changes are anti-correlated and enriched in gene bodies. a Spearman’s rank correlation of Δβ-5mC (oxBS) and Δβ-5hmC at 425 overlapping DMPs/DhMPs (adjusted P value < 0.05). Regression line, P value (p) and Spearman’s rank correlation coefficient (r) are given. Scatterplots (b) and boxplots (c) of 5mC (purple), BS (green) and 5hmC (orange) Δβ-values at 425 overlapping DMPs/DhMPs (adjusted P value < 0.05). Boxplots of β-values (left panel), distribution (in comparison to background, bkg) (top right panel) and Δβ-values between multiple sclerosis cases (MS, n = 10) and non-neurological controls (Ctr, n = 7) (bottom right panel) for BS-DMPs, 5mC-DMPs and 5hmC-DhMPs (adjusted P value < 0.05) across d classical gene features (shades of blue) including promoter-like features (TSS1500, TSS200, 1stExon, 5′UTR), gene body and 3′UTR and e CGI-related features (shades of red) including CpG islands, shores, shelves and open sea. In all boxplots, the black line represents the median, the interquartile range is comprised by a box and whiskers are extended to maximum and minimum Δβ values. *p < 0.05, **p < 0.01 and ***p < 0.001 using Fisher’s exact test for enrichment and depletion analyses (full data are shown in Additional file 1: Figure S9)

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