Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study

Table 4 Association between CpG1 site of the IGF2 gene and lipids among GRECF study participants

		Age- and sex-adjusted model*		P _interaction ^†	Fully adjusted model**		P _interaction ^§
		Beta( SE)	P	P _interaction ^†	Beta (SE)	P	P _interaction ^§
LDL-C	Overall	0.70 (0.44)	0.12	0.50	0.63 (0.44)	0.15	0.64
	Male	0.24 (0.79)	0.76		0.22 (0.76)	0.77
	Female	0.89 (0.55)	0.11		0.71 (0.55)	0.20
HDL-C	Overall	0.20 (0.18)	0.27	0.87	0.17 (0.18)	0.35	0.97
	Male	0.16 (0.31)	0.60		0.17 (0.33)	0.60
	Female	0.22 (0.23)	0.34		0.11 (0.23)	0.64
logTG	Overall	0.18 (0.28)	0.52	0.46	0.14 (0.29)	0.63	0.38
	Male	− 0.12 (0.56)	0.83		− 0.21 (0.56)	0.71
	Female	0.31 (0.30)	0.31		0.39 (0.31)	0.22
Total cholesterol	Overall	1.09 (0.49)	0.03	0.70	0.94 (0.48)	0.05	0.79
	Male	0.84 (0.91)	0.36		0.66 (0.89)	0.46
	Female	1.20 (0.57)	0.04		1.00 (0.58)	0.09

LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, logTG logarithmically transformed triglycerides, SE standard error
*Adjusted for age and sex among the overall sample; when stratified by gender, age was adjusted among male and female, respectively
^†Assessed by adding an interaction term, gender × CpG1 to the age- and sex-adjusted model among the overall participants
**Adjusted for age, sex, smoking, drinking, and education level among the overall sample; when stratified by gender, age, smoking, drinking, and education level were adjusted among male and female, respectively
^§Assessed by adding an interaction term, gender × CpG1 to the fully adjusted model among the overall participants

ISSN: 1868-7083