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Table 3 Association of exposure to severe famine with CpG1 site of the IGF2 gene among GRECF study participants

From: Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study

  

Age- and sex-adjusted model*

Pinteraction†

Fully adjusted model**

Pinteraction§

Methylation

 

Beta( SE)

P

Beta( SE)

P

Overall

Overall

0.005 (0.01)

0.70

0.89

0.004 (0.01)

0.75

0.91

 

Male

0.005 (0.02)

0.78

0.003 (0.02)

0.87

 

Female

0.006 (0.02)

0.76

0.003 (0.02)

0.88

CpG1 site

Overall

0.07 (0.02)

0.0008

0.18

0.07 (0.02)

0.002

0.15

 

Male

0.04 (0.02)

0.09

0.03 (0.03)

0.24

 

Female

0.10 (0.03)

0.004

0.10 (0.04)

0.008

CpG2 site

Overall

− 0.01 (0.02)

0.82

0.56

− 0.01 (0.03)

0.78

0.73

 

Male

0.005 (0.03)

0.88

− 0.002 (0.04)

0.95

 

Female

− 0.01(0.04)

0.72

− 0.008 (0.04)

0.84

CpG3 site

Overall

0.02 (0.02)

0.42

0.08

0.02 (0.02)

0.41

0.07

 

Male

0.05 (0.03)

0.04

0.06 (0.03)

0.03

 

Female

− 0.02 (0.03)

0.54

− 0.02 (0.03)

0.45

CpG4 site

Overall

− 0.02 (0.02)

0.27

0.71

− 0.02 (0.02)

0.24

0.52

 

Male

− 0.01 (0.02)

0.54

− 0.01 (0.02)

0.63

 

Female

− 0.03 (0.03)

0.36

− 0.04 (0.03)

0.22

CpG5 site

Overall

0.01 (0.01)

0.24

0.64

0.01 (0.01)

0.29

0.83

 

Male

0.008 (0.01)

0.33

0.005 (0.01)

0.53

 

Female

0.007 (0.01)

0.47

0.01 (0.01)

0.33

CpG6 and CpG7 site

Overall

− 0.02 (0.01)

0.13

0.24

− 0.02 (0.01)

0.15

0.38

 

Male

− 0.004 (0.02)

0.78

− 0.002 (0.02)

0.91

 

Female

− 0.04 (0.02)

0.11

− 0.04 (0.02)

0.12

CpG8 site

Overall

− 0.02 (0.02)

0.44

0.56

− 0.02 (0.02)

0.27

0.75

 

Male

− 0.005 (0.02)

0.83

− 0.019 (0.02)

0.41

 

Female

− 0.03 (0.03)

0.43

− 0.04 (0.03)

0.26

  1. SE standard error
  2. *Adjusted for age and sex among the overall sample; adjusted for age among male and female, respectively
  3. †Assessed by adding an interaction term, gender × famine severity to the age- and sex-adjusted model among the overall participants
  4. **Adjusted for age, sex, smoking, drinking, and education level among the overall sample
  5. §Assessed by adding an interaction term, gender × famine severity to the fully adjusted model among the overall participants