Skip to main content

Table 2 Association of exposure to severe famine with lipids among GRECF study participants

From: Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study

   Age- and sex-adjusted model* P interaction Fully adjusted model** Pinteraction§
   Beta ( SE) P Beta( SE) P
HDL-C Overall 0.10 (0.05) 0.04 0.17 0.11 (0.05) 0.04 0.30
  Male 0.03 (0.07) 0.63 0.04 (0.07) 0.56
  Female 0.17 (0.07) 0.02 0.15 (0.08) 0.06
LDL-C Overall 0.55 (0.12) 1.03 × 10−5 0.55 0.52 (0.12) 3.71 × 10−5 0.90
  Male 0.47 (0.17) 6.26 × 10−3 0.48 (0.17) 5.79 × 10−3
  Female 0.62 (0.17) 5.65 × 10−4 0.53 (0.18) 4.48 × 10−3
logTG Overall 0.12 (0.08) 0.12 0.41 0.10 (0.08) 0.22 0.52
  Male 0.20 (0.12) 0.11 0.16 (0.13) 0.23
  Female 0.04 (0.10) 0.68 0.09 (0.11) 0.42
Total cholesterol Overall 0.72 (0.13) 1.09 × 10−7 0.98 0.67 (0.13) 1.28 × 10−6 0.74
  Male 0.73 (0.19) 2.48 × 10−4 0.68 (0.20) 1.01 × 10−3
  Female 0.71 (0.18) 1.57 × 10−4 0.63 (0.19) 1.09 × 10−3
  1. LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, logTG logarithmically transformed triglycerides, SE standard error
  2. *Adjusted for age and sex among the overall sample; adjusted for age among male and female, respectively
  3. Assessed by adding an interaction term, gender × famine severity to the age- and sex-adjusted model among the overall participants
  4. **Adjusted for age, sex, smoking, drinking, and education level among the overall sample
  5. §Assessed by adding an interaction term, gender × famine severity to the fully adjusted model among the overall participants