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Table 1 Top 10 CpG sites of the PRS methylomic exploration in association with CPR (1400 CpG sites tested)

From: Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene

# CpG probea Genomic coordinatesb Gene PRS explorationc Intrapaird
beta p value q value beta p value
1 cg06793497 22: 41,542,898 EP300 0.021 8.2E-05 0.115 0.027 0.001
2 cg15620905 1: 44,024,150 PTPRF 0.040 0.002 0.804 0.008 0.563
3 cg12252443 2: 198,364,630 HSPD1 -0.006 0.002 0.804 − 0.007 0.055
4 cg24936500 2: 233,499,637 EFHD1 0.022 0.004 0.804 0.001 0.849
5 cg00262246 3: 136,007,461 PCCB 0.012 0.004 0.804 0.012 0.029
6 cg22495590 5: 138,161,059 CTNNA1 -0.020 0.004 0.804 − 0.010 0.203
7 cg14902598 5: 138,210,650 CTNNA1 0.017 0.005 0.804 0.006 0.371
8 cg01024069 14: 104,158,878 KLC1 -0.010 0.005 0.804 − 0.010 0.033
9 cg16362480 16: 30,077,084 ALDOA 0.031 0.005 0.804 0.024 0.126
10 cg12955069 16: 58,593,852 CNOT1; SNORA50 -0.016 0.006 0.804 − 0.021 0.026
  1. a CpG site code according to the Illumina annotation
  2. bGenomic coordinates correspond to hg19 built
  3. cRefers to the statistics of each analysis in the first model encompassing 1400 CpG sites located in genes of the PRS for schizophrenia highly expressed in the placenta as described by Ursini et al.
  4. dRefers to intrapair comparison of DNA methylation values and CPR. Thus, the n for these analyses was of 26 twin pairs