Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene

Table 1 Top 10 CpG sites of the PRS methylomic exploration in association with CPR (1400 CpG sites tested)

#	CpG probe^a	Genomic coordinates^b	Gene	PRS exploration^c			Intrapair^d
#	CpG probe^a	Genomic coordinates^b	Gene	beta	p value	q value	beta	p value
1	cg06793497	22: 41,542,898	EP300	0.021	8.2E-05	0.115	0.027	0.001
2	cg15620905	1: 44,024,150	PTPRF	0.040	0.002	0.804	0.008	0.563
3	cg12252443	2: 198,364,630	HSPD1	-0.006	0.002	0.804	− 0.007	0.055
4	cg24936500	2: 233,499,637	EFHD1	0.022	0.004	0.804	0.001	0.849
5	cg00262246	3: 136,007,461	PCCB	0.012	0.004	0.804	0.012	0.029
6	cg22495590	5: 138,161,059	CTNNA1	-0.020	0.004	0.804	− 0.010	0.203
7	cg14902598	5: 138,210,650	CTNNA1	0.017	0.005	0.804	0.006	0.371
8	cg01024069	14: 104,158,878	KLC1	-0.010	0.005	0.804	− 0.010	0.033
9	cg16362480	16: 30,077,084	ALDOA	0.031	0.005	0.804	0.024	0.126
10	cg12955069	16: 58,593,852	CNOT1; SNORA50	-0.016	0.006	0.804	− 0.021	0.026

^a CpG site code according to the Illumina annotation
^bGenomic coordinates correspond to hg19 built
^cRefers to the statistics of each analysis in the first model encompassing 1400 CpG sites located in genes of the PRS for schizophrenia highly expressed in the placenta as described by Ursini et al.
^dRefers to intrapair comparison of DNA methylation values and CPR. Thus, the n for these analyses was of 26 twin pairs

ISSN: 1868-7083