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Table 3 Correlation analysis of oxidative stress markers in fetal neural tissues and differentially methylated CpG sites in CASP8

From: Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure

CpG sites N SOD, unit/mg protein GPx, unit/mg protein TAC, unit/mg protein MDA, nmol/mg protein PC, nmol/mg protein
ρ p ρ p ρ p ρ p ρ p
CASP8_CpG_1 31 − 0.078 0.675 − 0.225 0.224 0.023 0.903 0.103 0.582 − 0.423 0.018
CASP8_CpG_2 31 − 0.005 0.980 − 0.091 0.627 0.038 0.840 0.093 0.618 − 0.266 0.148
CASP8_CpG_3 31 − 0.023 0.903 − 0.202 0.277 0.128 0.491 0.100 0.591 − 0.313 0.086
CASP8_CpG_4 31 − 0.128 0.493 − 0.186 0.317 0.022 0.907 0.073 0.696 − 0.256 0.164
CASP8_CpG_5 31 − 0.068 0.716 − 0.233 0.207 0.037 0.842 0.136 0.467 − 0.185 0.320
CASP8_CpG_6 31 0.006 0.976 − 0.402 0.025 0.144 0.440 0.183 0.323 − 0.029 0.875
CASP8_CpG_7 30 − 0.386 0.035 − 0.542 0.002 0.284 0.128 0.352 0.057 − 0.228 0.226
CASP8_average 31 − 0.114 0.540 − 0.265 0.149 0.110 0.555 0.132 0.478 − 0.266 0.148
  1. Note: SOD superoxide dismutase, GPx glutathione peroxidase, TAC total antioxidant capacity, MDA malondialdehyde, PC protein carbonyl, ρ Pearson’s correlation coefficient