Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure

Clinical Epigenetics

Table 2 Correlation analysis of differentially methylated CpG sites and PAH concentrations in maternal serum

CpG sites	N	Total PAHs, ng/g lipid		L_PAHs, ng/g lipid		H_PAHs, ng/g lipid
CpG sites	N	ρ	p	ρ	p	ρ	p
CASP8_CpG_1	56	− 0.242	0.072	− 0.221	0.102	− 0.275	0.040
CASP8_CpG_2	58	− 0.275	0.037	− 0.257	0.051	− 0.290	0.027
CASP8_CpG_3	58	− 0.212	0.109	− 0.182	0.171	− 0.255	0.053
CASP8_CpG_4	58	− 0.250	0.058	− 0.212	0.111	− 0.296	0.024
CASP8_CpG_5	58	− 0.165	0.216	− 0.125	0.352	− 0.228	0.086
CASP8_CpG_6	58	0.011	0.937	0.061	0.650	− 0.101	0.450
CASP8_CpG_7	56	− 0.157	0.247	− 0.136	0.319	− 0.201	0.137
CASP8_average	58	− 0.239	0.071	− 0.199	0.134	− 0.299	0.023

Note: PAHs, polycyclic aromatic hydrocarbons; total PAHs, sum of all PAHs; L_PAHs, sum of low-molecular-weight PAHs, including acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, and retene; H_PAHs, sum of high-molecular-weight PAHs, including pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, and benzo[a]pyrene; ρ, Pearson’s correlation coefficient.

ISSN: 1868-7083