Fig. 3
From: Functional roles of lncRNAs and its potential mechanisms in neuropathic pain
LncRNAs modulate pain signal transmission by mediating P2X receptors. As can be seen from the Figure, overexpression of lncRNAs can upregulate the expression of P2X7 and P2X3 receptor in DRG neurons, induce the release of inflammatory cytokines, or activate the pain-related signaling pathways, thereby activating the excitability of DRG neurons and ultimately promoting NP.