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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Fig. 2

Schematic of lncRNA-miRNA interactions in CCI rat models. a Ingenuity pathway analysis of differentially expressed lncRNAs mediated miRNA in CCT rat models. b XIST functions as “miRNA sponge” to reduce the expression levels of miRNA in NP, it prevents TFs (such as TNFAIP1, ZEB1, STAT3) from microRNA-mediated suppression, or directly decrease the release of inflammatory cytokines, thus alleviating the symptoms of NP. How the TFs affect the transcription of XIST is unclear. TNFAIP1 tumor necrosis factor alpha-induced protein 1, ZEB1 zinc-finger E-box binding homeobox 1, STAT3 signal transducer and activator of transcription 3, YY1 Yin-Yang 1, SGK3 glucocorticoid-regulated protein kinase 3, HMGB1 high mobility group 1, ZEB2 zinc-finger E-box binding homeobox 2

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