Fig. 1
From: Functional roles of lncRNAs and its potential mechanisms in neuropathic pain
Role of Kcna2 AS RNA under NP condition. Under NP condition, the increased expression of Kcna2 AS RNA can specifically and selectively inhibits the expression of Kcna2 mRNA, which then leads to the decreased expression level of Kcna2 channel and increased action potential and neuronal excitability in DRG neurons, producing central sensitization and ultimately alleviating the symptoms of NP.