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Table 1 Characteristics of the seven-CpG panel

From: Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas

Probe ID

Chr.

Relevant gene symbol

Relation to gene region

Relation to CpGs islandb

Multivariate Cox coefficientsa

á…Ÿcg23904249

11

CCDC86

TSS1500

Shore

1.095

cg07490776

8

AP3M2

TSS1500

Island

1.575

cg24035962

10

NCOA4

TSS200

Island

− 1.365

cg26647453

4

C4orf17

5′UTR

Open sea

− 1.574

cg01980222

6

TREM2

1stExon

Open sea

− 1.248

cg15227610

11

HSPB2

TSS1500

Open sea

− 1.120

cg13784557

6

HCP5

TSS200

Open sea

− 0.975

  1. Chr chromosome, TSS transcriptional start site
  2. aCox coefficients were calculated from multivariate analysis incorporating age, different discovery sets, MGMT methylation status, and the seven CpGs within the combined RT/TMZ discovery cohorts
  3. bOpen sea and shore refers to regions away from relevant CpGs islands more than 4000 bp or less than 2000 bp, respectively