Fig. 1
From: Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas
The identification of the 7-CpG signature. a The study workflow regarding the selection of predictive epigenetic panel. b Molecular and clinical correlations of the multi-CpG signature within TCGA-Brennan et al.-RT/TMZ. Heat maps of the methylation patterns of the 7 CpGs are presented, where each row represents a CpG, and each column represents a sample. Clinical and molecular features are indicated for each sample. ns not significant. c Patient classification by the 7-CpG RISK score classifier in two discovery cohorts of non-G-CIMP GBMs with RT/TMZ (RAUH-new cohort and TCGA-Brennan et al.) and one discovery cohort with RT alone (GSE60274);.GBM glioblastoma, G-CIMP glioma-CpGs island methylator phenotype, RT radiotherapy, TMZ temozolomide