Fig. 3
From: Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact
Methylation and expression of RNF130/miR-340 in primary bone marrow samples. a Representative M-MSP and U-MSP showing methylation of RNF130/miR-340-5p in primary samples of MGUS, diagnostic myeloma, and relapsed myeloma. The numbers were assigned for illustration purpose, and hence, the identical Arabic numerals in different disease stages are not serial samples from the same patient. b In 26 patients with both CD138-sorted DNA and RNA, there was a trend that patients with methylation of RNF130/miR-340 (n = 5) had a lower expression and hence larger ΔCt of mature miR-340-5p than patients without methylation (n = 21). c Kaplan-Meier analysis of OS in patients with and without methylation of RNF130/miR-340