UHRF1 depletion plus HDAC inhibition suppresses CRC cell proliferation. a Cell viability assays in DLD1 (left) and RKO (right) cells. Cells were transfected with the indicated siRNAs and incubated for 48 h, after which they were incubated with or without TSA for 24 h. Cell viabilities were assessed at the indicated time points. Shown are means of eight replications; error bars represent SDs. **P < 0.01, ***P < 0.001. b EdU cell proliferation assays in DLD1 (upper) and RKO (lower) cells treated with the indicated siRNAs alone or plus TSA. The results were confirmed in at least three independent experiments, and representative results are shown (also see Additional file 1: Figure S5).