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Fig. 2 | Clinical Epigenetics

Fig. 2

From: UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

Fig. 2

Infinium BeadChip assays revealing genome-wide DNA demethylation induced by UHRF1 depletion in CRC cells. Cells were transfected with control siRNA (siCONT) or siRNA targeting UHRF1, and genomic DNA was extracted 72 h (DLD1) or 96 h (RKO) after transfection. Density plots showing the β values of all probe sets in DLD1 (a) and RKO (b) cells transfected with the indicated siRNAs. c Box plots showing the β values of all probe sets or those located in CpG islands (CGI), CpG island shores (Shore), outside of CpG islands (Outside), transcription start sites and first exons (TSS-1stExon), gene bodies and 3′ untranslated regions (Body-3′URT), and intergenic regions (Intergenic) in DLD1 cells. ***P < 0.001. d Boxplots showing the β values of the indicated probe sets in RKO cells. ***P < 0.001

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