Gene/CpG site in Amplicon TREX2_2 or on 450K array (TCGA studies) | Observations/events, N/N | Univariable analysisa | Adjusted for age and gendera | ||
---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | ||
German larynx study | |||||
CpG 1,2 | 181/112 | 0.713 (0.295–1.722) | 0.4523 | 0.678 (0.278–1.654) | 0.7289 |
CpG 3,4 | 0.347 (0.120–1.002) | 0.0505 | 0.339 (0.118–0.978) | 0.0453 | |
CpG 5 | 1.197 (0.677–2.114) | 0.5364 | 1.078 (0.606–1.918) | 0.7984 | |
Average | 0.657 (0.237–1.822) | 0.4193 | 0.561 (0.198–1.592) | 0.2776 | |
TCGA laryngeal cancer cohort | |||||
cg09364317 | 119/52 | 0.176 (0.032–0.980) | 0.0473 | 0.106 (0.017–0.686) | 0.0184 |
cg18879010 | 0.146 (0.017–1.257) | 0.0798 | 0.207 (0.022–1.935) | 0.1673 | |
TREX2 mRNA expression | 118/52 | 0.766 (0.625–0.939) | 0.0104 | 0.726 (0.589–0.895) | 0.0027 |