Fig. 2

TREX2 methylation loss as a frequent event in multiple cancer studies. a Differential DNA methylation and b mRNA expression of TREX2 in multiple cancer studies (for abbreviations of cancer types, see Additional file 1: Table S1A). Graph shows a DNA methylation average at Illumina Infinium CpG probes cg09364317 and cg18879010 located at the TREX2 DMR and b TCGA Illumina HiSeq2000 RNAseq cohorts separated by primary tumor and normal tissue type. mRNA expression data depict RNA expression of the TREX2 transcript as log2(x + 1) transformed RSEM-normalized count. *p < 0.05. In addition, laryngeal cancer patients, a subgroup of HNSC patients with the ICD10-code C32, were evaluated for overall and pairwise differences in TREX2 DNA methylation (c) and mRNA expression (d)