ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Noro, Fabrizia; Gianfagna, Francesco; Gialluisi, Alessandro; De Curtis, Amalia; Di Castelnuovo, Augusto; Napoleone, Emanuela; Cerletti, Chiara; Donati, Maria Benedetta; de Gaetano, Giovanni; Hoylaerts, Marc F.; Iacoviello, Licia; Izzi, Benedetta

doi:10.1186/s13148-019-0665-6

Table 5 Association between ZBTB12 CpG-specific methylation and blood cell counts

From: ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Factor no.	CpG no.	White blood cells			Lymphocytes			Monocytes			Granulocytes			Platelets			Red blood cells
Factor no.	CpG no.	Beta	SE	p	Beta	SE	p	Beta	SE	p	Beta	SE	p	Beta	SE	p	Beta	SE	p
F1	3–4	− 0.110	0.046	0.018*	0.007	0.047	0.879	0.002	0.043	0.972	− 0.143	0.048	0.003*	− 0.030	0.043	0.492	0.033	0.040	0.409
	26	− 0.139	0.045	0.002*	− 0.011	0.047	0.809	− 0.049	0.042	0.253	− 0.166	0.046	0.0004*	− 0.086	0.042	0.042	− 0.003	0.039	0.942
	1	− 0.115	0.046	0.013*	− 0.009	0.048	0.854	0.015	0.044	0.736	− 0.143	0.048	0.003*	− 0.062	0.044	0.166	− 0.036	0.040	0.373
	11	− 0.120	0.050	0.016*	− 0.098	0.052	0.059	− 0.018	0.049	0.710	− 0.101	0.051	0.050	0.007	0.047	0.885	0.004	0.044	0.936
	5	− 0.116	0.048	0.016*	0.039	0.050	0.434	− 0.056	0.046	0.219	− 0.151	0.050	0.003*	− 0.037	0.045	0.406	− 0.003	0.042	0.947
	27	− 0.109	0.048	0.023	− 0.002	0.050	0.967	− 0.007	0.046	0.884	− 0.134	0.050	0.007*	− 0.012	0.046	0.801	− 0.015	0.043	0.728
	18–20	− 0.012	0.048	0.808	− 0.130	0.049	0.009	− 0.059	0.045	0.190	0.053	0.049	0.281	0.008	0.045	0.866	− 0.076	0.042	0.073
	6	0.006	0.047	0.903	0.020	0.048	0.672	− 0.031	0.044	0.485	0.002	0.048	0.960	0.042	0.044	0.341	0.089	0.040	0.027
F2	9–10	− 0.049	0.046	0.291	− 0.026	0.048	0.591	0.027	0.044	0.540	− 0.058	0.048	0.230	− 0.036	0.044	0.413	− 0.006	0.040	0.880
	21	− 0.014	0.047	0.766	0.009	0.049	0.856	0.011	0.045	0.814	− 0.029	0.048	0.551	− 0.050	0.045	0.264	− 0.034	0.040	0.400
	16	− 0.015	0.046	0.746	− 0.048	0.047	0.314	0.034	0.043	0.434	− 0.006	0.048	0.901	− 0.011	0.043	0.793	0.031	0.040	0.437
	8	− 0.055	0.047	0.234	− 0.015	0.048	0.763	0.029	0.044	0.510	− 0.071	0.048	0.142	− 0.004	0.045	0.928	− 0.059	0.040	0.145
	7^§	− 0.056	0.048	0.238	− 0.076	0.049	0.119	− 0.067	0.044	0.128	− 0.028	0.049	0.576	− 0.013	0.046	0.784	0.004	0.041	0.920

Model adjusted by age, gender, and smoking as fixed effects, and family stratification as a random effect; additional covariates were added to the model and were associated to both methylation factors and phenotypes (for blood cell counts, alcohol, and obesity). Standardized values of phenotypes and methylation are reported (beta values reported as standard deviation units). Significant p values are shown in italics
*pFDR significant
^§Factor loading for both Factor 1 and 2 lower than 0.40

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ISSN: 1868-7083

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