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Table 5 Association between ZBTB12 CpG-specific methylation and blood cell counts

From: ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Factor no. CpG no. White blood cells Lymphocytes Monocytes Granulocytes Platelets Red blood cells
Beta SE p Beta SE p Beta SE p Beta SE p Beta SE p Beta SE p
F1 3–4 − 0.110 0.046 0.018* 0.007 0.047 0.879 0.002 0.043 0.972 − 0.143 0.048 0.003* − 0.030 0.043 0.492 0.033 0.040 0.409
26 − 0.139 0.045 0.002* − 0.011 0.047 0.809 − 0.049 0.042 0.253 − 0.166 0.046 0.0004* − 0.086 0.042 0.042 − 0.003 0.039 0.942
1 − 0.115 0.046 0.013* − 0.009 0.048 0.854 0.015 0.044 0.736 − 0.143 0.048 0.003* − 0.062 0.044 0.166 − 0.036 0.040 0.373
11 − 0.120 0.050 0.016* − 0.098 0.052 0.059 − 0.018 0.049 0.710 − 0.101 0.051 0.050 0.007 0.047 0.885 0.004 0.044 0.936
5 − 0.116 0.048 0.016* 0.039 0.050 0.434 − 0.056 0.046 0.219 − 0.151 0.050 0.003* − 0.037 0.045 0.406 − 0.003 0.042 0.947
27 − 0.109 0.048 0.023 − 0.002 0.050 0.967 − 0.007 0.046 0.884 − 0.134 0.050 0.007* − 0.012 0.046 0.801 − 0.015 0.043 0.728
18–20 − 0.012 0.048 0.808 − 0.130 0.049 0.009 − 0.059 0.045 0.190 0.053 0.049 0.281 0.008 0.045 0.866 − 0.076 0.042 0.073
6 0.006 0.047 0.903 0.020 0.048 0.672 − 0.031 0.044 0.485 0.002 0.048 0.960 0.042 0.044 0.341 0.089 0.040 0.027
F2 9–10 − 0.049 0.046 0.291 − 0.026 0.048 0.591 0.027 0.044 0.540 − 0.058 0.048 0.230 − 0.036 0.044 0.413 − 0.006 0.040 0.880
21 − 0.014 0.047 0.766 0.009 0.049 0.856 0.011 0.045 0.814 − 0.029 0.048 0.551 − 0.050 0.045 0.264 − 0.034 0.040 0.400
16 − 0.015 0.046 0.746 − 0.048 0.047 0.314 0.034 0.043 0.434 − 0.006 0.048 0.901 − 0.011 0.043 0.793 0.031 0.040 0.437
8 − 0.055 0.047 0.234 − 0.015 0.048 0.763 0.029 0.044 0.510 − 0.071 0.048 0.142 − 0.004 0.045 0.928 − 0.059 0.040 0.145
  7§ − 0.056 0.048 0.238 − 0.076 0.049 0.119 − 0.067 0.044 0.128 − 0.028 0.049 0.576 − 0.013 0.046 0.784 0.004 0.041 0.920
  1. Model adjusted by age, gender, and smoking as fixed effects, and family stratification as a random effect; additional covariates were added to the model and were associated to both methylation factors and phenotypes (for blood cell counts, alcohol, and obesity). Standardized values of phenotypes and methylation are reported (beta values reported as standard deviation units). Significant p values are shown in italics
  2. *pFDR significant
  3. §Factor loading for both Factor 1 and 2 lower than 0.40