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Table 3 Association between ZBTB12 methylation factors and blood cell parameters

From: ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

  N Mean SD Associations between methylation factors and phenotypes
N Factor 1 Factor 2
Beta SE p Beta SE p
Functions
 Coagulation time (sec.) 417 395.51 77.66 313 − 0.007 0.052 0.891 0.051 0.052 0.333
 TNFɑ-stim. coagulation time (sec.) 417 350.90 72.89 313 − 0.021 0.056 0.709 0.160 0.056 0.0047*
  Delta coag. time (basal-TNF) (sec.) 417 44.60 56.53 313 − 0.034 0.052 0.510 0.145 0.052 0.0053*
 Platelet-monocyte aggr. (%) 450 7.81 9.06 337 0.107 0.045 0.019 0.005 0.046 0.912
 Platelet-PMN aggr. (%) 449 4.43 4.97 336 0.032 0.049 0.509 − 0.016 0.050 0.743
Blood cell count
 White blood cells (109/L) 458 6.38 1.48 318 − 0.161 0.054 0.0032* − 0.036 0.055 0.509
  Lymphocyte (109/L) 458 2.00 0.58 318 − 0.065 0.056 0.254 − 0.063 0.057 0.271
  Monocytes (109/L) 458 0.42 0.17 318 − 0.076 0.052 0.147 0.023 0.053 0.661
  Granulocytes (109/L) 458 3.96 1.17 318 − 0.158 0.056 0.0048* − 0.032 0.056 0.567
 Platelets (109/L) 458 253.82 61.84 318 − 0.050 0.052 0.335 − 0.044 0.053 0.407
 Red blood cells (109/L) 458 4.91 0.51 318 − 0.046 0.049 0.352 0.003 0.049 0.945
  1. Model adjusted by age, gender, and smoking as fixed effects and family stratification as a random effect; additional covariates were added to the model and were associated to both methylation factors and phenotypes (for blood cell counts, alcohol and obesity). Standardized values of phenotypes and methylation are reported (beta values reported as standard deviation units). Delta coag. time is obtained by the difference between unstimulated and TNFɑ-stimulated coagulation time. Significant p values are shown in italics
  2. *pFDR significant