CVD risk factors

Associations between methylation factors and phenotypes



Factor 1

Factor 2



N

Mean

SD

N

Beta

SE

pvalue

Beta

SE

p value

Age (years)

458

42.80

18.83

342

0.005

0.003

0.696

− 0.001

0.003

0.806

Leisuretime physical activity (MET/day)

449

2.31

1.07

336

− 0.111

0.052

0.035

− 0.066

0.052

0.206


N

n

%
 
Delta

SD

p value

Delta

SD

p value

Males

458

236

53.7%

342

0.031

0.105

0.768

− 0.148

0.104

0.157

Ever smokers

458

212

46.2%

342

0.182

0.115

0.113

− 0.024

0.114

0.831

Alcohol (> 15 g/day)

422

93

22.0%

319

− 0.013

0.139

0.925

− 0.415

0.135

0.0024*

Hypertension

456

162

35.5%

341

0.040

0.146

0.783

− 0.186

0.144

0.198

Dyslipidemia

456

191

41.9%

341

0.179

0.116

0.125

− 0.150

0.115

0.193

Obesity

456

93

20.4%

341

0.298

0.145

0.041

0.165

0.145

0.256

Diabetes

458

26

5.7%

342

0.159

0.232

0.495

− 0.003

0.230

0.988

 Model adjusted by age and gender as fixed effects and family stratification as a random effect. Significant p values are shown in italics
 MET metabolic equivalent of task
 *pFDR significant (alcohol, pFDR = 0.043)