ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

Table 2 Association between ZBTB12 methylation factors and CVD risk factors

CVD risk factors				Associations between methylation factors and phenotypes
CVD risk factors					Factor 1			Factor 2
	N	Mean	SD	N	Beta	SE	p-value	Beta	SE	p value
Age (years)	458	42.80	18.83	342	0.005	0.003	0.696	− 0.001	0.003	0.806
Leisure-time physical activity (MET/day)	449	2.31	1.07	336	− 0.111	0.052	0.035	− 0.066	0.052	0.206
	N	n	%		Delta	SD	p value	Delta	SD	p value
Males	458	236	53.7%	342	0.031	0.105	0.768	− 0.148	0.104	0.157
Ever smokers	458	212	46.2%	342	0.182	0.115	0.113	− 0.024	0.114	0.831
Alcohol (> 15 g/day)	422	93	22.0%	319	− 0.013	0.139	0.925	− 0.415	0.135	0.0024*
Hypertension	456	162	35.5%	341	0.040	0.146	0.783	− 0.186	0.144	0.198
Dyslipidemia	456	191	41.9%	341	0.179	0.116	0.125	− 0.150	0.115	0.193
Obesity	456	93	20.4%	341	0.298	0.145	0.041	0.165	0.145	0.256
Diabetes	458	26	5.7%	342	0.159	0.232	0.495	− 0.003	0.230	0.988

Model adjusted by age and gender as fixed effects and family stratification as a random effect. Significant p values are shown in italics
MET metabolic equivalent of task
*pFDR significant (alcohol, pFDR = 0.043)

ISSN: 1868-7083