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Table 2 Association between ZBTB12 methylation factors and CVD risk factors

From: ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort

CVD risk factors Associations between methylation factors and phenotypes
  Factor 1 Factor 2
  N Mean SD N Beta SE p-value Beta SE p value
Age (years) 458 42.80 18.83 342 0.005 0.003 0.696 − 0.001 0.003 0.806
Leisure-time physical activity (MET/day) 449 2.31 1.07 336 − 0.111 0.052 0.035 − 0.066 0.052 0.206
  N n %   Delta SD p value Delta SD p value
Males 458 236 53.7% 342 0.031 0.105 0.768 − 0.148 0.104 0.157
Ever smokers 458 212 46.2% 342 0.182 0.115 0.113 − 0.024 0.114 0.831
Alcohol (> 15 g/day) 422 93 22.0% 319 − 0.013 0.139 0.925 − 0.415 0.135 0.0024*
Hypertension 456 162 35.5% 341 0.040 0.146 0.783 − 0.186 0.144 0.198
Dyslipidemia 456 191 41.9% 341 0.179 0.116 0.125 − 0.150 0.115 0.193
Obesity 456 93 20.4% 341 0.298 0.145 0.041 0.165 0.145 0.256
Diabetes 458 26 5.7% 342 0.159 0.232 0.495 − 0.003 0.230 0.988
  1. Model adjusted by age and gender as fixed effects and family stratification as a random effect. Significant p values are shown in italics
  2. MET metabolic equivalent of task
  3. *pFDR significant (alcohol, pFDR = 0.043)