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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk

Fig. 1

EWAS identifies CpG sites significantly associated with ELEE in EPIC-Italy. An EWAS with DNA methylation (HM450K beta values) as outcome and ELEE as exposure was conducted in EPIC-Italy (n = 216) using a beta regression model adjusted for age, BMI, alcohol consumption, and smoking duration (all variables reported at recruitment), and batch, position on batch, and WBC composition. a Manhattan plot of minus log10Q values for FDR-corrected P values from the EWAS of all 404,596 probes across the genome. Blue line indicates FDR Q value threshold of 0.05. b Volcano plot of the regression coefficients (estimates) from the beta regression model, showing significant hypomethylated (in blue) and hypermethylated probes (in purple)

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Clinical Epigenetics

ISSN: 1868-7083

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