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Table 4 IC50 values of cellular viability for osteosarcoma cell lines (Saos-2, U-2OS, MG63, IOR/OS9, IOR/OS20, IOR/SARG, PDX-OS#1-C4) after 96 h of treatment with MC3353 or DAC

From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Compound IC50 ± SDa, μM
Saos-2 U-2OS MG63 IOR/OS9 IOR/OS20 IOR/SARG PDX-OS#1-C4
MC3353 1.1 ± 0.3 1.4 ± 0.1 2.4 ± 1.7 2.0 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 2.0 ± 0.1
DAC 1.0 ± 0.9 1.1 ± 0.9 0.2 ± 0.2 5.7 ± 3.4 9.2 ± 2.2 5.4 ± 1.0 0.7 ± 0.6
  1. SD standard deviation
  2. aData are the mean of at least two independent experiments