Table 4 IC50 values of cellular viability for osteosarcoma cell lines (Saos-2, U-2OS, MG63, IOR/OS9, IOR/OS20, IOR/SARG, PDX-OS#1-C4) after 96 h of treatment with MC3353 or DAC
From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Compound | IC50 ± SDa, μM | ||||||
|---|---|---|---|---|---|---|---|
Saos-2 | U-2OS | MG63 | IOR/OS9 | IOR/OS20 | IOR/SARG | PDX-OS#1-C4 | |
MC3353 | 1.1 ± 0.3 | 1.4 ± 0.1 | 2.4 ± 1.7 | 2.0 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 2.0 ± 0.1 |
DAC | 1.0 ± 0.9 | 1.1 ± 0.9 | 0.2 ± 0.2 | 5.7 ± 3.4 | 9.2 ± 2.2 | 5.4 ± 1.0 | 0.7 ± 0.6 |