From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Compound | IC50 ± SDa, μM (Selectivity indexb) | |||||||
---|---|---|---|---|---|---|---|---|
KG-1 | U-937 | RAJI | PC-3 | MDA-MB-231 | RPMI1788 | PBMCs | PHA_PBMCsc | |
MC3353 | 0.3 ± 0.0 | 0.4 ± 0.0 | 0.4 ± 0.0 | 0.9 ± 0.4 | 0.9 ± 0.7 | 2.4 ± 0.2 | 8.9 ± 4.2 | 4.6 ± 0.5 |
(IC50 RPMI1788/IC50 cell line) | (7.2) | (6.6) | (6.3) | (2.7) | (2.6) | (NA) | (NA) | (NA) |
(IC50 PBMCs/IC50 cell line) | (26.2) | (24.0) | (23.1) | (9.8) | (9.7) | (NA) | (NA) | (NA) |
(IC50 PHA_PBMCs/IC50 cell line) | (13.5) | (12.4) | (11.9) | (5.1) | (5.0) | (NA) | (NA) | (NA) |
SGI-1027 | 3.6 ± 0.6 | 1.7 ± 1.5 | 7.8 ± 0.7 | 5.0 ± 0.6 | 8.5 ± 7.2 | 6.7 ± 1.3 | 18.1 ± 6.8 | ND |
(IC50 RPMI1788/IC50 cell line) | (1.9) | (3.9) | (0.9) | (1.3) | (0.8) | (NA) | (NA) | (NA) |
(IC50 PBMCs/IC50 cell line) | (5) | (10.6) | (2.3) | (3.6) | (2.1) | (NA) | (NA) | (NA) |