Table 2 Fold induction of the luciferase signal of the CMV-luc construct in MC3353 or SGI-1027 treated KG-1 cells
From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Compound | Luciferase expression (fold ± SDa) | |||||
|---|---|---|---|---|---|---|
0.1 μM | 1 μM | 5 μM | ||||
5 h | 24 h | 5 h | 24 h | 5 h | 24 h | |
MC3353 | 1.0 ± 0.05 | 1.1 ± 0.1 | 5.8 ± 0.9 | 4.4 ± 3.5* | 6.7 ± 0.8* | ND |
SGI-1027 | 1.2 ± 0.3 | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.5 ± 0.1 | 4.0 ± 1.2 | 9.8 ± 4.7* |