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Table 2 Fold induction of the luciferase signal of the CMV-luc construct in MC3353 or SGI-1027 treated KG-1 cells

From: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Compound Luciferase expression (fold ± SDa)
0.1 μM 1 μM 5 μM
5 h 24 h 5 h 24 h 5 h 24 h
MC3353 1.0 ± 0.05 1.1 ± 0.1 5.8 ± 0.9 4.4 ± 3.5* 6.7 ± 0.8* ND
SGI-1027 1.2 ± 0.3 0.9 ± 0.1 1.0 ± 0.1 1.5 ± 0.1 4.0 ± 1.2 9.8 ± 4.7*
  1. ND not detected, SD standard deviation
  2. *Partial toxic effect on KG-1 cells induced strong variations on promoter induction
  3. aAll experiments were performed from n = 2 to n = 4