Fig. 1From: Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETsDecreased 5mC and increased 5hmC in T2DM patients. a 5mC and b 5hmC contents in T2DM patients and controls. Linear regression analysis between glucose and c 5mC and d 5hmC in all subjects after controlling age and gender. e 5mC and (f) 5hmC contents in T2DM patients with (MD+) or without (MD−) macrovascular diseases and controls. 5mC and 5hmC contents were detected by HPLC-MS/MS, and data are expressed as the means ± SDBack to article page