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Table 2 Correlation analysis of CpG methylation levels of selected genes with their transcript expression profilesᅟ

From: DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

Gene name CpG site/s P value/FDR cutoff Methylation and transcript status by pyrosequencing and qPCR Correlation coefficient (R2); P value
AKR1C3 CpG-880 <  0.05 Hypomethylated upregulated − 0.53; 0.02*
CASR CpG-680 <  0.05 Hypomethylated upregulated − 0.74; <  0.0001*
GHRHR CpG-809 <  0.025 Hypomethylated upregulated − 0.669; 0.002*
CpG-721 − 0.501; 0.034
RETN CpG-177 <  0.05 Hypomethylated upregulated − 0.603; 0.029*
MAMLD1 CpG-129 <  0.016 Hypomethylated upregulated − 0.759; <  0.0001*
CpG-116 − 0.596; 0.007*
CpG-113 − 0.612; 0.005*
TNF CpG-242 <  0.025 Hypermethylated downregulated − 0.582; 0.011*
TF CpG-358 <  0.05 Hypomethylated downregulated − 0.162; 0.507
  1. CpG sites that showed significant difference between controls and PCOS in Fig. 3 were analyzed. P values < FDR cutoff values are marked as significant (*)