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Table 2 Correlation analysis of CpG methylation levels of selected genes with their transcript expression profilesá…Ÿ

From: DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

Gene name

CpG site/s

P value/FDR cutoff

Methylation and transcript status by pyrosequencing and qPCR

Correlation coefficient (R2); P value

AKR1C3

CpG-880

<  0.05

Hypomethylated upregulated

− 0.53; 0.02*

CASR

CpG-680

<  0.05

Hypomethylated upregulated

− 0.74; <  0.0001*

GHRHR

CpG-809

<  0.025

Hypomethylated upregulated

− 0.669; 0.002*

CpG-721

− 0.501; 0.034

RETN

CpG-177

<  0.05

Hypomethylated upregulated

− 0.603; 0.029*

MAMLD1

CpG-129

<  0.016

Hypomethylated upregulated

− 0.759; <  0.0001*

CpG-116

− 0.596; 0.007*

CpG-113

− 0.612; 0.005*

TNF

CpG-242

<  0.025

Hypermethylated downregulated

− 0.582; 0.011*

TF

CpG-358

<  0.05

Hypomethylated downregulated

− 0.162; 0.507

  1. CpG sites that showed significant difference between controls and PCOS in Fig. 3 were analyzed. P values < FDR cutoff values are marked as significant (*)