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Fig. 4 | Clinical Epigenetics

Fig. 4

From: DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

Fig. 4

Altered gene methylation can contribute to ovarian dysfuncion. The figure summarizes some of the processes that could be dysregulated in the follicular compartment of women, due to hypomethylation (indicated by green boxes) or hypermethylation (indicated by red boxes) of genes in cumulus granulosa cells (CGCs). AKR1C3, aldo-keto reductase family 1 member C3; AR, androgen receptor; CASR, calcium-sensing receptor; COC, cumulus-oophorus complex; FF, follicular fluid; FSH, follicle-stimulating hormone; FSHR, follicle-stimulating hormone receptor; GC, granulosa cells; IGF1; insulin-like growth factor 1; INS, insulin; MGC, mural granulosa cells; GHRHR, growth hormone-releasing hormone receptor; HAPLN1, hyaluronan and proteoglycan link protein 1; LH, luteinizing hormone; LHCGR, luteinizing hormone chorionic gonadotropin receptor; LIF, leukemia inhibitory factor; MAMLD1, mastermind-like domain containing 1; PTGER1, prostaglandin receptor E1; RETN, resistin; TC, theca cells; TF, transferrin; TNF, tumor necrosis factor alpha

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