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Table 1 Characteristics of the discovery cohort, Project Viva, and the independent replication cohort, Generation R Study

From: Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood

Characteristics Discovery cohort Project Viva N = 479 Replication cohort Generation R Study N = 999
Maternal Mean (SD) or n (%)
 Age, years 32.1 (5.4) 32.2 (4.3)
 Pre-pregnancy BMI, kg/m2 24.7 (5.2) 23.4 (3.9)
 Antidepressant use 14 (2.9%) 14 (1.4%)
 High anxiety 40 (9.0%)a 56 (5.8%)b
 Depression mid-pregnancy 33 (8.2%)a 31 (3.2%)b
 Race/ethnicity
  Non-Hispanic White 341 (71.2%) Dutch 931 (93.2%)
  Non-Hispanic Black 56 (11.7%) Non-Dutch Western 63 (6.3%)
  Hispanic 37 (7.7%) Non-western 5 (0.5%)
  Other 45 (9.4%)  
 College graduate or more education 317 (66.2%) 669 (67.0%)
 Smoking status
  Never 327 (68.3%) Never during pregnancy 772 (77.3%)
  Former 100 (20.9%) Quit when pregnancy was known 93 (9.3%)
  During pregnancy 52 (10.9%) Continued during pregnancy 134 (13.4%)
Perinatal/infant Mean (SD) or n (%)
 Cesarean delivery 79 (16.5%) 103 (10.3%)
 Gestational age at delivery, weeks 39.8 (1.4) 40.2 (1.4)
 Birth weight-for-gestational age, z-score 0.27 (1.0) 0.26 (0.87)c
 Female infant 229 (47.8%) 484 (48.4%)
  1. a34 missing data on maternal anxiety and 77 missing data on maternal depression in Project Viva
  2. b86 missing data on maternal depression and anxiety in the Generation R Study
  3. c1 missing data for birthweight-for-gestational age in Generation R Study