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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

Fig. 2

Enrichment of dcSSc differentially methylated CpGs in regions overlapping histone modifications in the Roadmap Epigenomics Project data. Statistically significant enrichment outside the 99.9th percentile (−log10 binomial p value ≥ 3.38) is colored red on the vertical axis. Panel shows marked enrichment for a histone modification representative of enhancers (H3K4me1) in blood cells (monocytes, hematopoietic stem cells, natural killer cells), fetal tissues (lung fibroblasts, large intestine, small intestine, adrenal gland, muscle leg, thymus), psoas muscle, and skin fibroblasts. Enrichment for a histone modification representative of polycomb-repressed regions (H3K27me3) was seen in hematopoietic stem cells

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