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Table 6 Univariate and multivariate logistic regression analyses for classification of prostate tumor vs normal prostate based on probe methylation

From: Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Gene Probe Univariate p value Univariate odds ratio 95% confidence interval Multivariate p value Multivariate odds ratio 95% confidence interval
ASB2 cg01956154 3.48E−05*** 0.3 0.17–0.53 0.72 1.46 0.18–11.84
ASB2 cg19949550 5.37E−11*** 0.18 0.11–0.30 0.09 0.3 0.070–1.20
ASB2 cg09247392 4.42E−07*** 0.09 0.04–0.24 0.18 0.12 0.010–2.60
ETNK2 cg20136584 4.89E−09*** 16.64 6.49–42.68 **0.0014 154.88 6.95–3449.78
ETNK2 cg21535580 6.27E−05*** 3.17 1.80–5.59 0.08 19.76 0.70–559.54
ETNK2 cg00103329 1.09E−08*** 8.27 4.01–17.07 0.26 11.95 0.15–933.7
ETNK2 cg01566404 1.38E−08*** 5.69 3.12–10.36 0.17 0.09 0.00–2.78
MEIS2 cg01958086 1.12E−14*** 2.85 2.19–3.72 0.73 0.81 0.24–2.70
MEIS2 cg03951374 < 2.00E−16*** 3.88 2.84–5.29 0.77 0.81 0.20–3.33
MEIS2 cg13800209 2.08E−12*** 2.57 1.97–3.34 0.064 1.88 0.96–3.66
MEIS2 cg07433663 < 2.00E−16*** 2.35 1.92–2.88 0.46 0.75 0.35–1.60
MEIS2 cg21643314 8.79E−13*** 3.77 2.62–5.43 0.71 0.79 0.23–2.72
NRG1 cg04773818 3.41E−14*** 2.08 1.72–2.52 0.67 0.85 0.40–1.80
NRG1 cg04555373 3.96E−14*** 3.18 2.35–4.28 0.071 4.67 0.88–24.94
NRG1 cg03430846 2.84E−14*** 3.5 2.54–4.84 0.31 0.44 0.090–2.11
NRG1 cg24946597 2.41E−11*** 2.82 2.08–3.83 0.81 0.9 0.37–2.16
NRG1 cg00614182 1.16E−13*** 3.76 2.65–5.34 *0.049 2.7 1.70–26.00
NTN1 cg14615768 < 2.00E−16*** 6.12 4.03–9.27 0.46 0.53 0.10–2.83
NTN1 cg17072465 0.000213*** 3.25 1.74–6.08 0.36 0.32 0.030–3.71
NUDT10 cg21844331 0.14 1.37 0.90–2.09 NA NA NA
NUDT10 cg22363867 4.44E−07*** 3.28 2.07–5.21 0.3 0.37 0.060–2.41
NUDT10 cg15159291 0.02* 2.82 1.18–6.78 0.35 0.18 0.00–6.51
NUDT10 cg00648125 4.38E−05*** 2.94 1.75–4.93 0.9 0.91 0.21–3.98
NUDT10 cg02975846 2.53E−05*** 2.7 1.70–4.29 0.19 3.84 0.52–28.62
NUDT10 cg20430749 0.023* 1.51 1.06–2.15 0.23 0.32 0.050–2.05
NUDT10 cg06481089 0.13 0.65 0.37–1.13 NA NA NA
NUDT10 cg09520583 6.25E−06*** 6.47 2.88–14.55 0.2 2.72 0.58–12.76
SRPX cg16626088 2.13E−08*** 26.69 8.46–84.23 0.99 1.01 0.090–11.53
SRPX cg14759284 4.31E−13*** 6 3.70–9.74 0.98 0.99 0.30–3.24
SRPX cg19736094 6.00E−13*** 5.11 3.44–7.58 0.57 0.62 0.12–3.14
SRPX cg17407511 < 2.00E−16*** 4.82 3.36–6.91 0.38 2.11 0.39–11.28
SRPX cg27485646 1.03E−11*** 6.98 3.99–12.23 0.56 0.66 0.16–2.66
SRPX cg03509565 8.40E−13** 8.04 4.54–14.23 0.073 5.25 0.85–32.27
  1. Odds ratios and p values presented for methylation M values (logistic-transformed beta values)
  2. Statistical significance indicated by asterisks: *0.01 < p < 0.05; ***p < 0.001