Promoter methylation of ADAMTS1 and BNC1 as potential biomarkers for early detection of pancreatic cancer in blood

Table 3 Methylation frequency of two-gene panel (ADAMTS1 and/or BNC1) vs frequency of CA 19-9 elevation in different stages of pancreatic ductal adenocarcinoma

Patients	Stage I (%)		Stage IIA (%)		Stage IIB (%)		Stages III–IV (%)
Patients	Positive/total	Positive (%)	Positive/total	Positive (%)	Positive/total	Positive (%)	Positive/total	Positive (%)
ADAMTS1	7/8	87.5	7/9	77.8	18/20	90	2/2	100
BNC1	5/8	62.5	5/9	55.6	13/20	65	2/2	100
ADAMTS1 and/or BNC1	8/8	100	8/9	88.9	20/20	100	2/2	100
CA 19-9 (n = 34)*	4/7	57.1	4/9	44.4	11/17	64.7	0/1	0
ADAMTS1 and/or BNC1 + CA 19-9	8/8	100	8/9	88.9	20/20	100	2/2	100

*Missing two CA 19-9 values, so % out of total recorded CA 19-9 values for each stage

ISSN: 1868-7083