TY - JOUR AU - Siegel, R. L. AU - Miller, K. D. AU - Jemal, A. PY - 2017 DA - 2017// TI - Cancer statistics, 2017 JO - CA Cancer J Clin VL - 67 UR - https://doi.org/10.3322/caac.21387 DO - 10.3322/caac.21387 ID - Siegel2017 ER - TY - JOUR AU - Bosetti, C. PY - 2012 DA - 2012// TI - Pancreatic cancer: overview of descriptive epidemiology JO - Mol Carcinog VL - 51 UR - https://doi.org/10.1002/mc.20785 DO - 10.1002/mc.20785 ID - Bosetti2012 ER - TY - JOUR AU - Worni, M. PY - 2013 DA - 2013// TI - Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008 JO - Pancreas VL - 42 UR - https://doi.org/10.1097/MPA.0b013e318291fbc5 DO - 10.1097/MPA.0b013e318291fbc5 ID - Worni2013 ER - TY - JOUR AU - Karmazanovsky, G. PY - 2005 DA - 2005// TI - Pancreatic head cancer: accuracy of CT in determination of resectability JO - Abdom Imaging VL - 30 UR - https://doi.org/10.1007/s00261-004-0279-z DO - 10.1007/s00261-004-0279-z ID - Karmazanovsky2005 ER - TY - JOUR AU - Garrido-Laguna, I. AU - Hidalgo, M. PY - 2015 DA - 2015// TI - Pancreatic cancer: from state-of-the-art treatments to promising novel therapies JO - Nat Rev Clin Oncol VL - 12 UR - https://doi.org/10.1038/nrclinonc.2015.53 DO - 10.1038/nrclinonc.2015.53 ID - Garrido-Laguna2015 ER - TY - STD TI - Cancer Stat Facts: Pancreatic Cancer. Pancreatic Cancer - Cancer Stat Facts. 2018. https://seer.cancer.gov/statfacts/html/pancreas.html. UR - https://seer.cancer.gov/statfacts/html/pancreas.html ID - ref6 ER - TY - JOUR AU - Ahuja, N. AU - Sharma, A. R. AU - Baylin, S. B. PY - 2016 DA - 2016// TI - Epigenetic therapeutics: a new weapon in the war against cancer JO - Annu Rev Med VL - 67 UR - https://doi.org/10.1146/annurev-med-111314-035900 DO - 10.1146/annurev-med-111314-035900 ID - Ahuja2016 ER - TY - JOUR AU - Esteller, M. PY - 1999 DA - 1999// TI - Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients JO - Cancer Res VL - 59 ID - Esteller1999 ER - TY - JOUR AU - Chan, T. A. AU - Baylin, S. B. PY - 2012 DA - 2012// TI - Epigenetic biomarkers JO - Curr Top Microbiol Immunol VL - 355 ID - Chan2012 ER - TY - JOUR AU - Hong, S. M. PY - 2008 DA - 2008// TI - Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas JO - Mod Pathol VL - 21 UR - https://doi.org/10.1038/modpathol.2008.157 DO - 10.1038/modpathol.2008.157 ID - Hong2008 ER - TY - JOUR AU - Hong, S. M. PY - 2012 DA - 2012// TI - Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-11-1718 DO - 10.1158/1078-0432.CCR-11-1718 ID - Hong2012 ER - TY - JOUR AU - Sato, N. PY - 2008 DA - 2008// TI - CpG island methylation profile of pancreatic intraepithelial neoplasia JO - Mod Pathol VL - 21 UR - https://doi.org/10.1038/modpathol.3800991 DO - 10.1038/modpathol.3800991 ID - Sato2008 ER - TY - JOUR AU - Schuebel, K. E. PY - 2007 DA - 2007// TI - Comparing the DNA hypermethylome with gene mutations in human colorectal cancer JO - PLoS Genet VL - 3 UR - https://doi.org/10.1371/journal.pgen.0030157 DO - 10.1371/journal.pgen.0030157 ID - Schuebel2007 ER - TY - JOUR AU - Jeschke, J. PY - 2012 DA - 2012// TI - Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen JO - Epigenetics VL - 7 UR - https://doi.org/10.4161/epi.20445 DO - 10.4161/epi.20445 ID - Jeschke2012 ER - TY - JOUR AU - Yi, J. M. PY - 2013 DA - 2013// TI - Novel methylation biomarker panel for the early detection of pancreatic cancer JO - Clin Cancer Res VL - 19 UR - https://doi.org/10.1158/1078-0432.CCR-12-3224 DO - 10.1158/1078-0432.CCR-12-3224 ID - Yi2013 ER - TY - JOUR AU - Hulbert, A. PY - 2017 DA - 2017// TI - Early detection of lung cancer using DNA promoter hypermethylation in plasma and sputum JO - Clin Cancer Res VL - 23 UR - https://doi.org/10.1158/1078-0432.CCR-16-1371 DO - 10.1158/1078-0432.CCR-16-1371 ID - Hulbert2017 ER - TY - JOUR AU - Matsubayashi, H. PY - 2006 DA - 2006// TI - DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-2664 DO - 10.1158/0008-5472.CAN-05-2664 ID - Matsubayashi2006 ER - TY - JOUR AU - Kanda, M. PY - 2013 DA - 2013// TI - Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts JO - Gut VL - 62 UR - https://doi.org/10.1136/gutjnl-2012-302823 DO - 10.1136/gutjnl-2012-302823 ID - Kanda2013 ER - TY - JOUR AU - Frebourg, T. PY - 1988 DA - 1988// TI - The evaluation of CA 19-9 antigen level in the early detection of pancreatic cancer. A prospective study of 866 patients JO - Cancer VL - 62 UR - https://doi.org/3.0.CO;2-H DO - 3.0.CO;2-H ID - Frebourg1988 ER - TY - JOUR AU - Goonetilleke, K. S. PY - 2007 DA - 2007// TI - Diagnostic and prognostic value of plasma tumor M2 pyruvate kinase in periampullary cancer: evidence for a novel biological marker of adverse prognosis JO - Pancreas VL - 34 UR - https://doi.org/10.1097/MPA.0b013e31802ee9c7 DO - 10.1097/MPA.0b013e31802ee9c7 ID - Goonetilleke2007 ER - TY - JOUR AU - Kaur, S. PY - 2012 DA - 2012// TI - Early diagnosis of pancreatic cancer: challenges and new developments JO - Biomark Med VL - 6 UR - https://doi.org/10.2217/bmm.12.69 DO - 10.2217/bmm.12.69 ID - Kaur2012 ER - TY - JOUR AU - Steinberg, W. PY - 1990 DA - 1990// TI - The clinical utility of the CA 19-9 tumor-associated antigen JO - Am J Gastroenterol VL - 85 ID - Steinberg1990 ER - TY - JOUR AU - Leon, S. A. PY - 1977 DA - 1977// TI - Free DNA in the serum of cancer patients and the effect of therapy JO - Cancer Res VL - 37 ID - Leon1977 ER - TY - JOUR AU - Gahan, P. B. AU - Swaminathan, R. PY - 2008 DA - 2008// TI - Circulating nucleic acids in plasma and serum. Recent developments JO - Ann N Y Acad Sci VL - 1137 UR - https://doi.org/10.1196/annals.1448.050 DO - 10.1196/annals.1448.050 ID - Gahan2008 ER - TY - STD TI - Karampini E, McCaughan F. Circulating DNA in solid organ cancers-analysis and clinical application. QJM. Int J Med. 2016;109(4):223–7. ID - ref25 ER - TY - JOUR AU - Cohen, J. D. PY - 2017 DA - 2017// TI - Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers JO - Proc Natl Acad Sci U S A VL - 114 UR - https://doi.org/10.1073/pnas.1704961114 DO - 10.1073/pnas.1704961114 ID - Cohen2017 ER - TY - JOUR AU - Cohen, J. D. PY - 2018 DA - 2018// TI - Detection and localization of surgically resectable cancers with a multi-analyte blood test JO - Science VL - 359 UR - https://doi.org/10.1126/science.aar3247 DO - 10.1126/science.aar3247 ID - Cohen2018 ER - TY - JOUR AU - Guzzetta, A. A. PY - 2014 DA - 2014// TI - The promise of methylation on beads for cancer detection and treatment JO - Expert Rev Mol Diagn VL - 14 UR - https://doi.org/10.1586/14737159.2014.943665 DO - 10.1586/14737159.2014.943665 ID - Guzzetta2014 ER - TY - JOUR AU - Keeley, B. PY - 2013 DA - 2013// TI - Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events JO - Clin Chim Acta VL - 425 UR - https://doi.org/10.1016/j.cca.2013.07.023 DO - 10.1016/j.cca.2013.07.023 ID - Keeley2013 ER - TY - JOUR AU - Pandol, S. PY - 2012 DA - 2012// TI - Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell JO - J Gastroenterol Hepatol VL - 27 UR - https://doi.org/10.1111/j.1440-1746.2011.07013.x DO - 10.1111/j.1440-1746.2011.07013.x ID - Pandol2012 ER - TY - JOUR AU - Yeo, T. P. PY - 2015 DA - 2015// TI - Demographics, epidemiology, and inheritance of pancreatic ductal adenocarcinoma JO - Semin Oncol VL - 42 UR - https://doi.org/10.1053/j.seminoncol.2014.12.002 DO - 10.1053/j.seminoncol.2014.12.002 ID - Yeo2015 ER - TY - JOUR AU - Midha, S. AU - Chawla, S. AU - Garg, P. K. PY - 2016 DA - 2016// TI - Modifiable and non-modifiable risk factors for pancreatic cancer: a review JO - Cancer Lett VL - 381 UR - https://doi.org/10.1016/j.canlet.2016.07.022 DO - 10.1016/j.canlet.2016.07.022 ID - Midha2016 ER - TY - STD TI - A stool DNA test (Cologuard) for colorectal cancer screening. Jama. 2014;312(23):2566. ID - ref33 ER - TY - STD TI - Cai L, Hood S, Kallam E, Overman D, Barker K, et al. Epi proColon®: Use of a non-invasive SEPT9 gene methylation blood test for colorectal cancer screening: A national laboratory experience. J Clin Epigenet. 2018;4:7. https://doi.org/10.21767/2472-1158.100092. ID - ref34 ER - TY - JOUR AU - Vos, T. PY - 2009 DA - 2009// TI - Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer JO - Clin Chem VL - 55 UR - https://doi.org/10.1373/clinchem.2008.115808 DO - 10.1373/clinchem.2008.115808 ID - Vos2009 ER - TY - JOUR AU - Warren, J. D. PY - 2011 DA - 2011// TI - Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer JO - BMC Med VL - 9 UR - https://doi.org/10.1186/1741-7015-9-133 DO - 10.1186/1741-7015-9-133 ID - Warren2011 ER - TY - JOUR AU - Rakovitch, E. PY - 2017 DA - 2017// TI - Multigene expression assay and benefit of radiotherapy after breast conservation in ductal carcinoma in situ JO - J Natl Cancer Inst VL - 109 UR - https://doi.org/10.1093/jnci/djw256 DO - 10.1093/jnci/djw256 ID - Rakovitch2017 ER - TY - JOUR AU - Renfro, L. A. PY - 2017 DA - 2017// TI - Prospective evaluation of a 12-gene assay on patient treatment decisions and physician confidence in mismatch repair proficient stage IIA colon cancer JO - Clin Colorectal Cancer VL - 16 UR - https://doi.org/10.1016/j.clcc.2016.07.016 DO - 10.1016/j.clcc.2016.07.016 ID - Renfro2017 ER - TY - JOUR AU - Eeden, S. K. PY - 2018 DA - 2018// TI - A biopsy-based 17-gene genomic prostate score as a predictor of metastases and prostate cancer death in surgically treated men with clinically localized disease JO - Eur Urol VL - 73 UR - https://doi.org/10.1016/j.eururo.2017.09.013 DO - 10.1016/j.eururo.2017.09.013 ID - Eeden2018 ER - TY - JOUR AU - Esteller, M. PY - 2001 DA - 2001// TI - A gene hypermethylation profile of human cancer JO - Cancer Res VL - 61 ID - Esteller2001 ER - TY - JOUR AU - Tsai, H. C. AU - Baylin, S. B. PY - 2011 DA - 2011// TI - Cancer epigenetics: linking basic biology to clinical medicine JO - Cell Res VL - 21 UR - https://doi.org/10.1038/cr.2011.24 DO - 10.1038/cr.2011.24 ID - Tsai2011 ER - TY - BOOK AU - Howlader, N. AU - Noone, A. M. AU - Krapcho, M. AU - Miller, D. AU - Bishop, K. AU - Kosary, C. L. AU - Yu, M. AU - Ruhl, J. AU - Tatalovich, Z. AU - Mariotto, A. AU - Lewis, D. R. AU - Chen, H. S. AU - Feuer, E. J. AU - Cronin, K. A. PY - 2017 DA - 2017// TI - SEER Cancer Statistics Review, 1975-2014 PB - National Cancer Institute CY - Bethesda ID - Howlader2017 ER - TY - JOUR AU - Henschke, C. I. PY - 2006 DA - 2006// TI - Survival of patients with stage I lung cancer detected on CT screening JO - N Engl J Med VL - 355 UR - https://doi.org/10.1056/NEJMoa060476 DO - 10.1056/NEJMoa060476 ID - Henschke2006 ER - TY - BOOK PY - 2017 DA - 2017// TI - Colorectal Cancer Facts & Figures 2017-2019 PB - American Cancer Society CY - Atlanta ID - ref44 ER - TY - JOUR AU - Egawa, S. PY - 2004 DA - 2004// TI - Clinicopathological aspects of small pancreatic cancer JO - Pancreas VL - 28 UR - https://doi.org/10.1097/00006676-200404000-00004 DO - 10.1097/00006676-200404000-00004 ID - Egawa2004 ER - TY - STD TI - Hur C, et al. Early pancreatic ductal adenocarcinoma survival is dependent on size: positive implications for future targeted screening. Pancreas. 2016;45(7):1062–6. ID - ref46 ER - TY - JOUR AU - Marchegiani, G. PY - 2017 DA - 2017// TI - Does size matter in pancreatic cancer?: reappraisal of tumour dimension as a predictor of outcome beyond the TNM JO - Ann Surg VL - 266 UR - https://doi.org/10.1097/SLA.0000000000001837 DO - 10.1097/SLA.0000000000001837 ID - Marchegiani2017 ER - TY - JOUR AU - Lennon, A. M. PY - 2014 DA - 2014// TI - The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? JO - Cancer Res VL - 74 UR - https://doi.org/10.1158/0008-5472.CAN-14-0734 DO - 10.1158/0008-5472.CAN-14-0734 ID - Lennon2014 ER - TY - JOUR AU - Wagner, M. PY - 2004 DA - 2004// TI - Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma JO - Br J Surg VL - 91 UR - https://doi.org/10.1002/bjs.4484 DO - 10.1002/bjs.4484 ID - Wagner2004 ER - TY - JOUR AU - Griffin, J. F. AU - Poruk, K. E. AU - Wolfgang, C. L. PY - 2015 DA - 2015// TI - Pancreatic cancer surgery: past, present, and future JO - Chin J Cancer Res VL - 27 ID - Griffin2015 ER - TY - JOUR AU - Rulyak, S. J. PY - 2003 DA - 2003// TI - Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindreds JO - Gastrointest Endosc VL - 57 UR - https://doi.org/10.1067/mge.2003.28 DO - 10.1067/mge.2003.28 ID - Rulyak2003 ER - TY - JOUR AU - Shin, E. J. AU - Canto, M. I. PY - 2012 DA - 2012// TI - Pancreatic cancer screening JO - Gastroenterol Clin N Am VL - 41 UR - https://doi.org/10.1016/j.gtc.2011.12.001 DO - 10.1016/j.gtc.2011.12.001 ID - Shin2012 ER - TY - JOUR AU - Verna, E. C. PY - 2010 DA - 2010// TI - Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics JO - Clin Cancer Res VL - 16 UR - https://doi.org/10.1158/1078-0432.CCR-09-3209 DO - 10.1158/1078-0432.CCR-09-3209 ID - Verna2010 ER - TY - JOUR AU - Li, D. PY - 2004 DA - 2004// TI - Pancreatic cancer JO - Lancet VL - 363 UR - https://doi.org/10.1016/S0140-6736(04)15841-8 DO - 10.1016/S0140-6736(04)15841-8 ID - Li2004 ER - TY - JOUR AU - Petersen, G. M. PY - 2006 DA - 2006// TI - Pancreatic cancer genetic epidemiology consortium JO - Cancer Epidemiol Biomarkers Prev VL - 15 UR - https://doi.org/10.1158/1055-9965.EPI-05-0734 DO - 10.1158/1055-9965.EPI-05-0734 ID - Petersen2006 ER - TY - JOUR AU - Rustgi, A. K. PY - 2014 DA - 2014// TI - Familial pancreatic cancer: genetic advances JO - Genes Dev VL - 28 UR - https://doi.org/10.1101/gad.228452.113 DO - 10.1101/gad.228452.113 ID - Rustgi2014 ER - TY - JOUR AU - Yeo, T. P. PY - 2002 DA - 2002// TI - Pancreatic cancer JO - Curr Probl Cancer VL - 26 UR - https://doi.org/10.1067/mcn.2002.129579 DO - 10.1067/mcn.2002.129579 ID - Yeo2002 ER - TY - JOUR AU - Humphris, J. L. PY - 2014 DA - 2014// TI - Clinical and pathologic features of familial pancreatic cancer JO - Cancer VL - 120 UR - https://doi.org/10.1002/cncr.28863 DO - 10.1002/cncr.28863 ID - Humphris2014 ER - TY - JOUR AU - Petersen, G. M. PY - 2015 DA - 2015// TI - Familial pancreatic adenocarcinoma JO - Hematol Oncol Clin North Am VL - 29 UR - https://doi.org/10.1016/j.hoc.2015.04.007 DO - 10.1016/j.hoc.2015.04.007 ID - Petersen2015 ER - TY - JOUR AU - Canto, M. I. PY - 2013 DA - 2013// TI - International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer JO - Gut VL - 62 UR - https://doi.org/10.1136/gutjnl-2012-303108 DO - 10.1136/gutjnl-2012-303108 ID - Canto2013 ER - TY - JOUR AU - Aberle, D. R. PY - 2011 DA - 2011// TI - Reduced lung-cancer mortality with low-dose computed tomographic screening JO - N Engl J Med VL - 365 UR - https://doi.org/10.1056/NEJMoa1102873 DO - 10.1056/NEJMoa1102873 ID - Aberle2011 ER - TY - JOUR AU - Anderson, M. A. PY - 2012 DA - 2012// TI - Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: a multicenter study JO - Am J Gastroenterol VL - 107 UR - https://doi.org/10.1038/ajg.2012.288 DO - 10.1038/ajg.2012.288 ID - Anderson2012 ER - TY - JOUR AU - Pang, T. PY - 2017 DA - 2017// TI - A novel scoring system to analyze combined effect of lifestyle factors on pancreatic cancer risk: a retrospective case-control study JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-13182-w DO - 10.1038/s41598-017-13182-w ID - Pang2017 ER - TY - JOUR AU - Melo, S. A. PY - 2015 DA - 2015// TI - Glypican-1 identifies cancer exosomes and detects early pancreatic cancer JO - Nature VL - 523 UR - https://doi.org/10.1038/nature14581 DO - 10.1038/nature14581 ID - Melo2015 ER - TY - STD TI - Babic A, Wolpin BM. Circulating exosomes in pancreatic cancer: will they succeed on the long, littered road to early detection marker? Clin Chem. 2016;62(2):307–9. ID - ref65 ER - TY - JOUR AU - Bailey, V. J. PY - 2010 DA - 2010// TI - Single-tube analysis of DNA methylation with silica superparamagnetic beads JO - Clin Chem VL - 56 UR - https://doi.org/10.1373/clinchem.2009.140244 DO - 10.1373/clinchem.2009.140244 ID - Bailey2010 ER - TY - JOUR AU - Bailey, V. J. PY - 2009 DA - 2009// TI - MS-qFRET: a quantum dot-based method for analysis of DNA methylation JO - Genome Res VL - 19 UR - https://doi.org/10.1101/gr.088831.108 DO - 10.1101/gr.088831.108 ID - Bailey2009 ER - TY - JOUR AU - Bustin, S. A. PY - 2009 DA - 2009// TI - The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments JO - Clin Chem VL - 55 UR - https://doi.org/10.1373/clinchem.2008.112797 DO - 10.1373/clinchem.2008.112797 ID - Bustin2009 ER -