Fig. 4

Association of methylation differences near the GREB1 locus and endometriosis risk. a Location of GREB1 transcripts on chromosome 2 with marked locations of the lead endometriosis risk SNP (rs11674184) for the GREB1 locus (pink), the GREB1 gene expression array probe (ILMN_1721170) position (purple), the location of mQTL DNAm probe (cg16908938) (orange) and mQTL SNP (rs59129126) (green) passing the SMR analysis. b Expression of ILMN_1721170 in endometrial samples from women with different genotypes at rs59129126. c Methylation at DNAm probe cg16908938 in endometrial samples from women with different genotypes at rs59129126. d SMR locus plot showing the results at GREB1/Metazoa_SRP locus for endometriosis. Results of the latest GWAS meta-analysis are shown in the top plot, grey dots representing the P values for SNPs and diamonds representing the P values for DNAm probe sites from the SMR test. Sites highlighted in red passed the SMR test. The middle and bottom plots show the endometrial mQTL P values of SNPs from this study for the DNAm probe sites nearest to GREB1 and Metazoa_SRP respectively