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Fig. 6 | Clinical Epigenetics

Fig. 6

From: The hyper-activation of transcriptional enhancers in breast cancer

Fig. 6

Genes associated with H3K4me3-enriched super-enhancer were highly related to breast cancer tumorigenesis. a Matchstick plot showing the top 10 KEGG pathway and top 5 specific expressed tissue associated with tumor H3K4me3-enriched super-enhancer-adjacent genes. b Scatter plot comparing tumor H3K4me3-enriched super-enhancer-adjacent genes expression (log2(FPKM + 2−5)) between normal tissue and tumor. All 275 genes were divided into four clusters. c Box plot of expression (log2(FPKM + 2−2)) from four gene clusters identified in 5C in both normal tissue and tumor three replicates. d, e Matchstick plots showing the top KEGG pathway (e) and specifically expressed tissue (f) terms of four gene clusters identified in 5C

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