Fig. 6

Changes in FACT-Cog score and CpG cg16936953 before and after chemotherapy. a FACT-Cog scores breast cancer patients at pre-chemotherapy and post-chemotherapy timepoints. Blue line indicates a decrease and yellow line indicates an increase in the score. Red line connects the median scores at the two timepoints. b Beta-values of CpG cg16936953 of breast cancer patients at pre-chemotherapy and post-chemotherapy timepoints. Blue line indicates a decrease and yellow line indicates an increase in the score. Red line connects the median scores at the two timepoints. c Correlation plot between the changes in FACT-Cog scores and the changes in beta-value of cg16936953 in breast cancer patients. The gray area around the blue regression line indicates 95% confidence intervals. Although data not shown, in cancer-free control, FACT-Cog scores were high at baseline, indicating no impairment, and did not change significantly over time