Fig. 5

The VMP1/MIR21 locus where the DNA methylation status was most significantly altered after chemotherapy. The log10-transformed p values of DNA methylation changes between before and after chemotherapy with adjustment for cell composition are plotted against the chromosome locations of the CpG probes in the 500 kb region centering on cg16936953, the most significant probe. The size of a triangle indicates the log-transformed methylation level change (logFC) and the direction of a triangle indicates hypermethylation vs. hypomethylation. The chromosome ideogram and known genes in this locus are shown at the top of the plot