Fig. 4

Venn diagram of significant CpG sites in multivariate models. The change of DNA methylation for each CpG site between pre- and post-chemotherapy was tested in linear regression models with adjustment for estimated leukocyte composition as the base model (base model), and in addition, for chemotherapy regimen (anthracycline vs. non-anthracycline), accumulative dose chemotherapeutic drugs, accumulative dose of growth factors administered, and accumulative dose of steroids administered. Significant CpG sites across the above five models are displayed in Venn diagram. Cutoff of significance level was set at 1e-7 for adjusting for approximately 500,000 tests