Fig. 3

Circos plot of significant changes in blood DNA methylome before and after chemotherapy with adjustment for leukocyte composition. Leukocyte CpG sites that were significantly altered between pre- and post-chemotherapy after adjustment for leukocyte composition are displayed in circos plot. The inner most circle shows the 23 chromosomes. CpG sites organized based on chromosomal position and log-transformed p values are shown as closed dots, with significant CpG sites highlighted in blue (p < 1e-7 as shown in the red circular line). Symbols for the 460 genes annotated for those CpG sites are shown in the outer circles