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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study

Fig. 1

Manhattan plots of changes in leukocyte DNA methylome. Beta-values of each CpG site was compared between paired samples collected from the same individual at two separate time points, and p values from paired test were log-transformed and plotted based on chromosomal position. The red line indicates the cutoff significance level of 1e-7 after adjusting for approximately 500,000 tests. a Paired peripheral blood samples collected from breast cancer patients at pre- and post-chemotherapy time points with a median of 128 days apart (range 71–230 days). b Paired peripheral blood samples collected from healthy controls at two separate time points with a median of 130 days apart (range 42–453 days)

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