Fig. 7

SOM-analysis of gene expression data. a SOM-portraits of gene expression in normal intestinal samples of untreated or radiated 4- and 12-month-old mice and tumors of 12-month-old Msh2^−/− mice. Color codes for gene expression which was normalized to the maximum (red) and minimum (blue) expression within the individual sample. b GSZ score of expression for the “DNA repair” and “ribosome” gene sets. Following the loss of Msh2 or a single-radiation hit, the epigenetic profile of these sets is dominated by Set1 genes. (Fig. 6b, Additional file 5). An increased variability of the expression is seen in 12- compared to 4-month-old mice. Gene expression is strongly upregulated in tumors