Fig. 5

Epigenetic changes induced by a single-radiation hit. a, b The histone modification state distribution for differentially modified genes comparing non-radiated with radiated Msh2^+/+ (a, 10389 genes) and Msh2^−/− mice (b, 3495 genes). c, d The transition matrices for non-radiated and radiated Msh2^+/+ (c) and Msh2^−/− (d) mice. The matrix in c emphasizes the recruitment of H3K36me3 to histones carrying a single H3K4me3 mark (Set1^rad) and recruitment of H3K4me3 to H3K27me3 and unmodified genes (Set2^rad) in Msh2^+/+ mice. The transition matrix in d shows no prominent enrichment comparing non-radiated and radiated Msh2^−/− mice. e Number of genes carrying an H3K4me3-H3K36me3 histone mark [101] in non-radiated mice and their radiated counterparts. The darker part of the columns of radiated mice indicates the fraction of genes that are also modified in non-radiated mice